Document Detail

Preoperative aspirin resistance does not increase myocardial injury during off-pump coronary artery bypass surgery.
MedLine Citation:
PMID:  21860554     Owner:  NLM     Status:  MEDLINE    
We performed a prospective cohort trial on 220 patients undergoing elective off-pump coronary artery bypass surgery and taking aspirin to evaluate the effect of aspirin resistance on myocardial injury. The patients were divided into aspirin responders and aspirin non-responders by the value of the aspirin reaction units obtained preoperatively using the VerifyNow™ Aspirin Assay. The serum levels of troponin I were measured before surgery and 1, 6, 24, 48 and 72 hr after surgery. In-hospital major adverse cardiac and cerebrovascular events, graft occlusion, the postoperative blood loss and reexploration for bleeding were recorded. Of the 220 patients, 181 aspirin responders (82.3%) and 39 aspirin non-responders (17.7%) were defined. There were no significant differences in troponin I levels (ng/mL) between aspirin responders and aspirin non-responders: preoperative (0.04 ± 0.08 vs 0.03 ± 0.06; P = 0.56), postoperative 1 hr (0.72 ± 0.87 vs 0.86 ± 1.10; P = 0.54), 6 hr (2.92 ± 8.76 vs 1.50 ± 2.40; P = 0.94), 24 hr (4.16 ± 13.44 vs 1.25 ± 1.95; P = 0.52), 48 hr (2.15 ± 7.06 vs 0.65 ± 0.95; P = 0.64) and 72 hr (1.20 ± 4.63 vs 0.38 ± 0.56; P = 0.47). Moreover, no significant differences were observed with regard to in-hospital outcomes. In conclusion, preoperative aspirin resistance does not increase myocardial injury in patients undergoing off-pump coronary artery bypass surgery. Postoperative dual antiplatelet therapy might have protected aspirin resistant patients.
Hyun Joo Kim; Jung-Man Lee; Jeong Hwa Seo; Jun-Hyeon Kim; Deok-Man Hong; Jae-Hyon Bahk; Ki-Bong Kim; Yunseok Jeon
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Publication Detail:
Type:  Journal Article     Date:  2011-07-27
Journal Detail:
Title:  Journal of Korean medical science     Volume:  26     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-23     Completed Date:  2011-12-12     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1041-6     Citation Subset:  IM    
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
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MeSH Terms
Aspirin / administration & dosage*
Cohort Studies
Coronary Artery Bypass, Off-Pump / adverse effects*
Coronary Disease / surgery*
Drug Resistance
Middle Aged
Myocardial Infarction / etiology
Myocardial Reperfusion Injury / prevention & control*
Platelet Aggregation Inhibitors / administration & dosage*
Postoperative Hemorrhage / etiology
Preoperative Care / methods
Prospective Studies
Stroke / etiology
Troponin I / blood
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 0/Troponin I; 50-78-2/Aspirin

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