Document Detail


Preoperative 6-minute walk test adds prognostic information to Euroscore in patients undergoing aortic valve replacement.
MedLine Citation:
PMID:  19561363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The authors investigated the additive prognostic value of the 6-minute walk test (6MWT) to Euroscore in patients with severe aortic stenosis undergoing aortic valve replacement (AVR) METHODS AND RESULTS: 208 patients with severe AS underwent the 6MWT before AVR, as part of a randomised trial (ASSERT) comparing stented and stentless aortic valves. Clinical follow-up was available for 200 patients up to 12 months. The rate of death, myocardial infarction (MI) or stroke (time to first event) was 13% (n = 14) in patients walking <300 metres compared to 4% (n = 4) in those who walked > or =300 metres (p = 0.017). When rate of death, MI or stroke by Euroscore risk was stratified by 6-minute walking distance, the 6MWT added prognostic information. In a Cox regression analysis 6MWT distance was the only variable retained as an independent predictor of the composite outcome of death, MI or stroke at 12 months (HR 0.28 95% CI 0.09 to 0.85, p = 0.025).
CONCLUSIONS: The 6MWT is safe and feasible to carry out in patients with severe aortic stenosis before AVR, and provides potentially important functional and prognostic information to clinical assessment and the Euroscore risk score.
Authors:
D P de Arenaza; J Pepper; B Lees; F Rubinstein; F Nugara; M Roughton; M Jasinski; O Bazzino; M Flather;
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-06-28
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-11     Completed Date:  2010-03-25     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  AIM; IM    
Affiliation:
Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aortic Valve
Aortic Valve Stenosis / surgery*
Exercise / physiology*
Exercise Test / methods*
Female
Heart Failure / diagnosis*
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation / instrumentation
Humans
Kaplan-Meier Estimate
Male
Preoperative Care
Prognosis
Stents
Walking / physiology*
Investigator
Investigator/Affiliation:
John Pepper / ; Marek Jasinski / ; Mons Lie / ; Andrzej Bochenek / ; Levent Guvendik / ; Jullien Gaer / ; Per Erling Dahl / ; Jon Anderson / ; Pankaj Mankad /
Comments/Corrections
Comment In:
Heart. 2010 Jan;96(2):97-8   [PMID:  19858135 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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