Document Detail

Prenylated xanthones from Garcinia xanthochymus.
MedLine Citation:
PMID:  14600386     Owner:  NLM     Status:  MEDLINE    
A new prenylated xanthone, 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone (1), was isolated from the wood of Garcinia xanthochymus together with a known xanthone, garciniaxanthone E (2). Their structures were determined by spectroscopic analysis. Compounds 1 (3 microM) and 2 (10 microM) elicited marked enhancement of nerve growth factor-mediated neurite outgrowth in PC12D cells.
Wisinee Chanmahasathien; Yushan Li; Masayuki Satake; Yasukatsu Oshima; Masami Ishibashi; Nijsiri Ruangrungsi; Yasushi Ohizumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  51     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-06-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1332-4     Citation Subset:  IM    
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
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MeSH Terms
Drug Synergism
Garcinia / chemistry*
Magnetic Resonance Spectroscopy
Nerve Growth Factors / pharmacology
Neurites / drug effects
PC12 Cells
Plant Extracts / chemistry
Protein Prenylation
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Xanthones / chemistry*,  isolation & purification,  pharmacology
Reg. No./Substance:
0/Nerve Growth Factors; 0/Plant Extracts; 0/Xanthones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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