Document Detail


Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.
MedLine Citation:
PMID:  10737704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line. All the prenylchalcones and prenylflavanones tested were found to induce QR but not CYP1A1 in this cell line. In contrast, the synthetic chalcone, chalconaringenin, and the flavanone, naringenin, with no prenyl or geranyl groups, were ineffective in inducing QR. The hop chalcones, xanthohumol and dehydrocycloxanthohumol hydrate, also induced QR in the Ah-receptor-defective mutant cell line, Hepa 1c1c7 bp(r)c1. Thus, the prenylflavonoids represent a new class of monofunctional inducers of QR.
Authors:
C L Miranda; G L Aponso; J F Stevens; M L Deinzer; D R Buhler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  149     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-11     Completed Date:  2000-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Affiliation:
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chalcone / pharmacology*
Enzyme Induction / drug effects
Flavanones*
Flavonoids / pharmacology*
Liver Neoplasms, Experimental / enzymology*
Mice
NAD(P)H Dehydrogenase (Quinone) / metabolism*
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
ES00210/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Flavanones; 0/Flavonoids; 487-26-3/flavanone; 94-41-7/Chalcone; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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