| Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. | |
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MedLine Citation:
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PMID: 10737704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line. All the prenylchalcones and prenylflavanones tested were found to induce QR but not CYP1A1 in this cell line. In contrast, the synthetic chalcone, chalconaringenin, and the flavanone, naringenin, with no prenyl or geranyl groups, were ineffective in inducing QR. The hop chalcones, xanthohumol and dehydrocycloxanthohumol hydrate, also induced QR in the Ah-receptor-defective mutant cell line, Hepa 1c1c7 bp(r)c1. Thus, the prenylflavonoids represent a new class of monofunctional inducers of QR. |
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Authors:
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C L Miranda; G L Aponso; J F Stevens; M L Deinzer; D R Buhler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer letters Volume: 149 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-04-11 Completed Date: 2000-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 21-9 Citation Subset: IM |
Affiliation:
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Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chalcone / pharmacology* Enzyme Induction / drug effects Flavanones* Flavonoids / pharmacology* Liver Neoplasms, Experimental / enzymology* Mice NAD(P)H Dehydrogenase (Quinone) / metabolism* Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
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ES00210/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Flavanones; 0/Flavonoids; 487-26-3/flavanone; 94-41-7/Chalcone; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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