| Prentice's approach and the meta-analytic paradigm: a reflection on the role of statistics in the evaluation of surrogate endpoints. | |
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MedLine Citation:
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PMID: 15339295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We put a perspective on the strengths and limitations of statistical methods for the evaluation of surrogate endpoints. Whereas using several trials overcomes some of the limitations of a single-trial framework (Prentice, 1989, Statistics in Medicine 8, 431-440), arguably the evaluation of surrogate endpoints can never be done using only statistical evidence but such evidence should be seen as but one component in a decision-making process that involves, among others, a number of clinical and biological considerations. We briefly present a hierarchical framework that incorporates ideas from Prentice's work and is uniformly applicable to different types of surrogate and true clinical outcomes. |
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Authors:
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Ariel Alonso; Geert Molenberghs; Tomasz Burzykowski; Didier Renard; Helena Geys; Ziv Shkedy; Fabián Tibaldi; José Cortiñas Abrahantes; Marc Buyse |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Biometrics Volume: 60 ISSN: 0006-341X ISO Abbreviation: Biometrics Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-01 Completed Date: 2005-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370625 Medline TA: Biometrics Country: United States |
Other Details:
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Languages: eng Pagination: 724-8 Citation Subset: IM |
Affiliation:
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Center for Statistics, Limburgs Universitair Centrum, Diepenbeek, Belgium. ariel.alonso@luc.ac.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biometry
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methods* Clinical Trials as Topic / statistics & numerical data* Endpoint Determination / statistics & numerical data* Humans Interferon Type I, Recombinant / therapeutic use Likelihood Functions Macular Degeneration / drug therapy, physiopathology Meta-Analysis as Topic* Models, Statistical Visual Acuity / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I, Recombinant |
| Comments/Corrections | |
Comment In:
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Biometrics. 2007 Sep;63(3):958-62; author reply 962-3
[PMID:
17825025
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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