Document Detail


Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
MedLine Citation:
PMID:  7195069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal chicks were made opiate-dependent by injections of N-desmethyl-1-alpha-acetylmethadol into the chorioallantois on day 3 of embryogenesis. The injections had no effect on subsequent hatchability; however, spontaneous fetal motility was significantly depressed. Injection of naloxone caused a significant increase in the motility of the opiate-exposed fetuses but had no effect on control fetuses. That naloxone's effect was an expression of opiate withdrawal and not due to antagonism of depressed motility is also supported by the observation that naloxone significantly reduced the hatchability of opiate-exposed chicks and not of control chicks. Thus the withdrawal of a developing organism from a narcotic may be more deleterious to its survival than continued exposure.
Authors:
M D Kuwahara; S B Sparber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  212     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  945-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo / drug effects*
Humans
Methadone / analogs & derivatives*
Methadyl Acetate / pharmacology*
Naloxone / pharmacology
Opioid-Related Disorders / physiopathology
Substance Withdrawal Syndrome / complications*
Grant Support
ID/Acronym/Agency:
DA01880/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
465-65-6/Naloxone; 509-74-0/Methadyl Acetate; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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