Document Detail

Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
MedLine Citation:
PMID:  7195069     Owner:  NLM     Status:  MEDLINE    
Fetal chicks were made opiate-dependent by injections of N-desmethyl-1-alpha-acetylmethadol into the chorioallantois on day 3 of embryogenesis. The injections had no effect on subsequent hatchability; however, spontaneous fetal motility was significantly depressed. Injection of naloxone caused a significant increase in the motility of the opiate-exposed fetuses but had no effect on control fetuses. That naloxone's effect was an expression of opiate withdrawal and not due to antagonism of depressed motility is also supported by the observation that naloxone significantly reduced the hatchability of opiate-exposed chicks and not of control chicks. Thus the withdrawal of a developing organism from a narcotic may be more deleterious to its survival than continued exposure.
M D Kuwahara; S B Sparber
Related Documents :
1169079 - Umbilical blood flow and glucose uptake in lamb fetus following single umbilical artery...
20097769 - Ductus venosus velocimetry in acute fetal acidemia and impending fetal death in a sheep...
2726599 - Two-dimensional and m-mode assessment of aortic growth in the normal and growth-retarde...
7617579 - Sonographic depiction of fetal tooth germs.
6889539 - Developmental trends of liver parenchyma in the terminal period of gestation: a stereol...
12523609 - Fetal lateral ventricular width: what should be its upper limit? a prospective cohort s...
2445209 - First-trimester serum levels of the beta-subunit of human chorionic gonadotropin in a t...
17061949 - Increase in regularity of fetal heart rate variability with age.
11489149 - Risks of hypertensive disorders in the second pregnancy.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  212     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  945-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chick Embryo / drug effects*
Methadone / analogs & derivatives*
Methadyl Acetate / pharmacology*
Naloxone / pharmacology
Opioid-Related Disorders / physiopathology
Substance Withdrawal Syndrome / complications*
Grant Support
Reg. No./Substance:
465-65-6/Naloxone; 509-74-0/Methadyl Acetate; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Opiate withdrawal in utero increases neonatal morbidity in the rat.
Next Document:  Phencyclidine, lysergic acid diethylamide, and mescaline: cerebral artery spasms and hallucinogenic ...