| Prenatal vitamin C status is associated with placental apoptosis in normal-term human pregnancies. | |
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MedLine Citation:
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PMID: 16564088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancy is associated with increased susceptibility to oxidative stress. Deficiencies in antioxidants during pregnancy and placental oxidant-antioxidant imbalance may impair the development of the fetoplacental unit or the eventual offspring. In order to elucidate the association of prenatal status of vitamin C with the oxidative stress and apoptotic activity in normal full-term placentas, we evaluated the content of placental lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and the trophoblast apoptotic index in normal-term human pregnancies. Tissue samples of placentas obtained from 80 normal-term pregnancies were categorized into 40 cases with a lower level of prenatal vitamin C (< 8.997 microg/ml) and 40 cases with a higher level of prenatal vitamin C (> or =11.734 microg/ml). We evaluated the placental LOX-1 content and the trophoblast apoptotic index with Western blot analysis and immunohistochemistry, and then determined their correlation with the prenatal status of vitamin C. We confirmed that the trophoblast expression for the endothelial scavenger receptor LOX-1 and the apoptotic activity were significantly lower in the group with a higher prenatal level of vitamin C, indicating that placental oxidative stress and the apoptotic index were associated with the maternal status of vitamin C. We therefore postulate that the maternal status of antioxidant vitamins during pregnancy can affect fetal development. |
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Authors:
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Y M Ahn; Y J Kim; H Park; B Park; H Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-24 |
Journal Detail:
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Title: Placenta Volume: 28 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-03-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 31-8 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Ewha Womans University Medical College, and Medical Research Center, Mok 6 Dong, Yangcheon Gu, Seoul 158-710, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apoptosis* Ascorbic Acid / blood* Female Humans Oxidative Stress Placenta / metabolism, physiology* Pregnancy* Scavenger Receptors, Class E / metabolism Term Birth / blood, metabolism Trophoblasts / physiology |
| Chemical | |
Reg. No./Substance:
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0/OLR1 protein, human; 0/Scavenger Receptors, Class E; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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