Document Detail


Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants.
MedLine Citation:
PMID:  21104995     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The objective of this study was to determine the consequences for HPA axis functioning among healthy full-term newborns of prenatal treatment with the synthetic glucocorticoid (GC), betamethasone, which is the routine treatment for threatened preterm delivery. Ninety full-term infants were recruited into two study groups (30 betamethasone treated; 60 comparison group matched for GA at birth and sex). The cortisol and behavioral response to the painful stress of a heel-stick blood draw was assessed 24 hr after birth. Full-term infants exposed to prenatal betamethasone displayed a larger cortisol response to the heel-stick procedure, despite no differences in baseline levels. Further, within the recommended window of betamethasone administration (24-34 gestational weeks), infants exposed to betamethasone earlier in gestation displayed the largest cortisol response to the heel-stick. These data add to accumulating evidence that prenatal exposure to elevated GCs programs the development of the HPA axis. © 2010 Wiley Periodicals, Inc.
Authors:
Elysia Poggi Davis; Feizal Waffarn; Curt A Sandman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-23
Journal Detail:
Title:  Developmental psychobiology     Volume:  -     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Psychiatry and Human Behavior, University of California, 333 City Blvd W., Suite 1200, Orange, CA 92868.
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