| Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency. | |
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MedLine Citation:
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PMID: 6334149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to prevent in utero virilization of female fetuses with 21-hydroxylase deficiency, six mothers at risk were treated with either hydrocortisone (n = 1) or dexamethasone (n = 5) in early pregnancy. Treatment was continued to term in the two pregnancies in which the diagnosis of an affected female fetus was confirmed. In patient 1 (hydrocortisone treatment) fetal adrenal suppression was only partial but the external genitalia were only slightly abnormal. In patient 2 (dexamethasone treatment) fetal adrenal suppression was achieved and the external genitalia were normal at birth. These encouraging results open a new prospect for treating congenital adrenal hyperplasia in utero. |
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Authors:
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M David; M G Forest |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 105 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1984-12-27 Completed Date: 1984-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 799-803 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxyprogesterone Adrenal Hyperplasia, Congenital* / drug therapy* Adult Amniotic Fluid / analysis Dexamethasone / therapeutic use Female Humans Hydrocortisone / therapeutic use Hydroxyprogesterones / blood Infant, Newborn Pregnancy Prenatal Care* Steroid Hydroxylases / deficiency* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxyprogesterones; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 68-96-2/17-alpha-Hydroxyprogesterone; EC 1.14.-/Steroid Hydroxylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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