Document Detail

Prenatal toxicity studies in rats and rabbits with the calcium channel blocker diproteverine.
MedLine Citation:
PMID:  8998385     Owner:  NLM     Status:  MEDLINE    
In prenatal toxicity studies, diproteverine, a calcium channel blocker with demonstrated antianginal properties, produced an unusual pattern of digital, heart, tail, and vertebral defects in rat fetuses from mothers treated during the major period of organogenesis, but only a very low incidence of heart abnormalities was seen in the rabbit. Heart changes were rarely seen in association with digital defects. The findings were consistent with those seen with other calcium channel blockers and add weight to the suggestion of Danielsson and colleagues (5) that digital malformations are a class effect for this type of compound, the effects being related to reduced uteroplacental blood flow. In addition, it is proposed that cardiovascular malformations are also a class response with calcium channel blockers. The distribution of fetal death and hemorrhages and the varying association between cardiovascular, digital, and tail abnormalities seen in the rat with increasing doses of diproteverine fits the pattern of changes reported following hypoxia in the chick embryo. Reduced uteroplacental blood flow with resultant embryonic hypoxia secondary to pharmacologic action is considered a probable mechanism of action for the induction of abnormalities produced by calcium channel blockers.
J E Ridings; A K Palmer; E J Davidson; J A Baldwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  10     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    1996 Jan-Feb
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Smithkline Beecham Pharmaceuticals, Toxicology Department UK, Welwyn, Hertfordshire, UK.
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MeSH Terms
Abnormalities, Multiple / chemically induced
Anoxia / chemically induced
Body Weight / drug effects
Calcium Channel Blockers / administration & dosage,  toxicity*
Embryonic and Fetal Development / drug effects*
Extremities / embryology
Fetal Resorption / chemically induced
Heart Defects, Congenital / chemically induced
Isoquinolines / administration & dosage,  toxicity*
Limb Deformities, Congenital
Placental Circulation / drug effects
Pregnancy, Animal / drug effects*
Prenatal Exposure Delayed Effects
Rats, Sprague-Dawley
Spine / abnormalities,  drug effects,  embryology
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Isoquinolines; 69373-95-1/diproteverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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