Document Detail


Prenatal tobacco exposure: developmental outcomes in the neonatal period.
MedLine Citation:
PMID:  21038943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Smoking during pregnancy is a persistent public health problem that has been linked to later adverse outcomes. The neonatal period--the first month of life--carries substantial developmental change in regulatory skills and is the period when tobacco metabolites are cleared physiologically. Studies to date mostly have used cross-sectional designs that limit characterizing potential impacts of prenatal tobacco exposure on the development of key self-regulatory processes and cannot disentangle short-term withdrawal effects from residual exposure-related impacts. In this study, pregnant participants (N = 304) were recruited prospectively during pregnancy, and smoking was measured at multiple time points, with both self-report and biochemical measures. Neonatal attention, irritable reactivity, and stress dysregulation were examined longitudinally at three time points during the first month of life, and physical growth indices were measured at birth. Tobacco-exposed infants showed significantly poorer attention skills after birth, and the magnitude of the difference between exposed and nonexposed groups attenuated across the neonatal period. In contrast, exposure-related differences in irritable reactivity largely were not evident across the 1st month of life, differing marginally at 4 weeks of age only. Third-trimester smoking was associated with pervasive, deleterious, dose–response impacts on physical growth measured at birth, whereas nearly all smoking indicators throughout pregnancy predicted level and growth rates of early attention. The observed neonatal pattern is consistent with the neurobiology of tobacco on the developing nervous system and fits with developmental vulnerabilities observed later in life.
Authors:
Kimberly Andrews Espy; Hua Fang; Craig Johnson; Christian Stopp; Sandra A Wiebe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Developmental psychology     Volume:  47     ISSN:  1939-0599     ISO Abbreviation:  Dev Psychol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-02-08     Completed Date:  2011-06-30     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0260564     Medline TA:  Dev Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Attention
Child Development*
Female
Follow-Up Studies
Humans
Infant, Newborn
Irritable Mood
Male
Pregnancy
Prenatal Exposure Delayed Effects / psychology*
Prospective Studies
Tobacco*
Grant Support
ID/Acronym/Agency:
DA015223/DA/NIDA NIH HHS; DA023653/DA/NIDA NIH HHS; HD050309/HD/NICHD NIH HHS; MH065668/MH/NIMH NIH HHS; R01 DA014661/DA/NIDA NIH HHS; R01 DA014661/DA/NIDA NIH HHS; R01 DA014661-01A2/DA/NIDA NIH HHS; R01 MH065668/MH/NIMH NIH HHS; R01 MH065668-01A2/MH/NIMH NIH HHS
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