Document Detail


Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female.
MedLine Citation:
PMID:  16413112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Findings discussed in this review stress the importance of normal estrogen and androgen signaling at appropriate developmental time points in maintaining normal phenotypic expression, reproductive and metabolic function and document how inappropriate steroid signaling, at inopportune times can have undesirable outcomes. For example, inappropriate testosterone exposure during fetal life alters the developmental trajectory of the female culminating in a suite of disorders, which include intrauterine growth-retardation and postnatal catch up growth, phenotypic masculinization, reproductive neuroendocrine and ovarian disruptions leading to progressive loss of cyclicity and metabolic disruptions manifested as hyperinsulinemia.
Authors:
Vasantha Padmanabhan; Mohan Manikkam; Sergio Recabarren; Douglas Foster
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-01-18
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  246     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2006-06-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  165-74     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109-0404, USA. vasantha@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Diseases / etiology
Metabolic Diseases / etiology*
Prenatal Diagnosis
Sheep
Signal Transduction*
Testosterone / pharmacology,  physiology*
Grant Support
ID/Acronym/Agency:
HD41098/HD/NICHD NIH HHS; P01 HD44232/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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