Document Detail

Prenatal stress and immune recognition of self and nonself in the primate neonate.
MedLine Citation:
PMID:  10516397     Owner:  NLM     Status:  MEDLINE    
The capacity of the neonate to respond to nonself antigens was evaluated in infant monkeys born after normal and disturbed pregnancies. Mixed lymphocyte cultures were used to test the infants' proliferative responses to mitomycin-treated stimulator cells, either from a genetically unrelated animal or from a virally transformed monkey cell line. Periods of daily stress for 6 weeks in mid-late pregnancy (months 3.0-4.5) resulted in a significant decrease in proliferative responses, whereas the same stressor early in pregnancy (months 1.5-3.0) increased responses by the neonate's cells. Similar to the late stress effect, an inhibition of proliferative responses by neonatal cells was induced by dexamethasone administered for 2 days late in pregnancy at 4.5 months after conception, 1 month before term. These findings demonstrate that certain immune responses at birth are extremely sensitive to prior prenatal events. Further, the bidirectional changes indicate that there may be critical periods in gestation when the same extrinsic events have radically different effects on the fetus.
C L Coe; G R Lubach; J W Karaszewski
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  76     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  301-10     Citation Subset:  IM    
Harlow Center for Biological Psychology, University of Wisconsin, Madison, WI 53706, USA.
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MeSH Terms
Animals, Newborn / immunology*
Autoantigens / immunology
Cells, Cultured
Dexamethasone / diagnostic use
Enzyme-Linked Immunosorbent Assay / veterinary
Glucocorticoids / diagnostic use
Housing, Animal
Hydrocortisone / blood
Infant, Newborn
Interleukin-2 / analysis,  blood
Lymphocyte Activation
Lymphocyte Culture Test, Mixed / veterinary
Macaca mulatta / immunology*,  psychology
Pregnancy, Animal / psychology*
Stress, Psychological / immunology*
Grant Support
Reg. No./Substance:
0/Autoantigens; 0/Glucocorticoids; 0/Interleukin-2; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone

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