Document Detail


Prenatal stress and epilepsy in later life: a nationwide follow-up study in Denmark.
MedLine Citation:
PMID:  18514486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine whether prenatal exposure to maternal bereavement is associated with an increased risk of epilepsy in the first decades of life. METHODS: We conducted a population-based cohort study of children (N=1,553,966) born in Denmark from 1978 to 2004. A total of 39,867 children born to women who lost a close relative while pregnant or within 1 year before the pregnancy were included in the exposed cohort. The main outcome of interest was hospitalization due to epilepsy (ICD 8 codes 345.00-345.99, ICD 10 codes G40.0-G41.9). We used log-linear Poisson models to estimate incidence rate ratios (IRRs). RESULTS: The exposed children had a risk of epilepsy similar to that of unexposed children (IRR 1.06, 95% CI 0.96-1.18). The IRRs were 1.08 (95% CI 0.89-1.31) for the children of women who lost a child, and 1.02 (95% CI 0.91-1.15) for the children of women who lost a partner, parent or sibling. The IRRs did not differ according to the timing of exposure or the causes of death (unexpected causes and other causes). CONCLUSIONS: Our data do not suggest any strong association between prenatal stress and epilepsy in the first decades of life.
Authors:
Jiong Li; Mogens Vestergaard; Carsten Obel; Dorthe Hansen Precht; Jakob Christensen; Michael Lu; Jørn Olsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-02
Journal Detail:
Title:  Epilepsy research     Volume:  81     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  52-7     Citation Subset:  IM    
Affiliation:
Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus C, Denmark. jl@soci.au.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Denmark / epidemiology
Education / statistics & numerical data
Epilepsy / epidemiology*,  etiology
Family
Female
Follow-Up Studies
Grief
Humans
Infant, Newborn
Maternal Age
Models, Statistical
Poisson Distribution
Pregnancy
Pregnancy Outcome
Prenatal Exposure Delayed Effects / epidemiology*
Registries
Stress, Psychological / complications,  epidemiology*

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