Document Detail

Prenatal stress and cognitive development and temperament in infants.
MedLine Citation:
PMID:  12829109     Owner:  NLM     Status:  MEDLINE    
Studies in rodents and nonhuman primates indicate that maternal stress during pregnancy can influence the developing fetus, resulting in delay of motor and cognitive development and impaired adaptation to stressful situations. These effects may be mediated by the hypothalamic-pituitary-adrenal (HPA) axis. We examined whether stress during pregnancy predicted developmental outcome of human infants in a prospective design. Self-report data about daily hassles and pregnancy-specific anxiety and salivary cortisol levels were collected in nulliparous pregnant women. Dependent measures were scores on the Bayley Scales of Infant Development and on temperamental questionnaires at 3 and 8 months. Pregnancy-specific anxiety in mid pregnancy predicted lower mental and motor developmental scores at 8 months. Early morning values of cortisol in late pregnancy were negatively related to both mental and motor development at 3 months and motor development at 8 months. Pregnancy-specific anxiety explained 7% of the variance of test-affectivity and goal-directedness at 8 months. Increased maternal stress during pregnancy seems to be one of the determinants of temperamental variation and delay of development of infants and may be a risk factor for developing psychopathology later in life.
Jan K Buitelaar; Anja C Huizink; Edu J Mulder; Pascalle G Robles de Medina; Gerard H A Visser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neurobiology of aging     Volume:  24 Suppl 1     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-06-27     Completed Date:  2003-09-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S53-60; discussion S67-8     Citation Subset:  IM    
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, P.O. Box 85500, Utrecht 3508 GA, The Netherlands.
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MeSH Terms
Cognition / physiology*
Infant Behavior / physiology*,  psychology
Prenatal Exposure Delayed Effects*
Stress, Physiological / embryology*,  psychology
Temperament / physiology*
Comment In:
Neurobiol Aging. 2003 May-Jun;24 Suppl 1:S61-5; discussion S67-8   [PMID:  12829110 ]

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