Document Detail

Prenatal screening for thrombophilia: the background and the approach.
MedLine Citation:
PMID:  15692216     Owner:  NLM     Status:  MEDLINE    
Coagulation is a normal response to blood vessel injury and involves the interaction of endothelium, platelets and clotting factors. Coagulation is altered by pregnancy and may be further altered by thrombophilia, an acquired or inherited predisposition to develop thrombosis. An overview of coagulation is provided as background for understanding thrombophilia. Both acquired and genetic risk factors for thrombosis are discussed. Thrombosis may affect not only the maternal circulation, but the utero-placental-fetal circulation as well. The literature documenting the association between maternal thrombosis and thrombophilia is summarized, as is the recent data linking thrombophilia and poor pregnancy outcome. An approach to screening for thrombophilia is outlined and strategies for thromboprophylaxis are provided.
Andra H James; Leo R Brancazio
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-02-03
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  60     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-27     Completed Date:  2005-11-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  47-57     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Blood Coagulation / physiology*
Fetal Diseases / diagnosis*
Fibrinolysis / physiology*
Mass Screening / methods
Pregnancy Complications, Hematologic / prevention & control*
Pregnancy Outcome
Prenatal Diagnosis / methods*
Thrombophilia / diagnosis*,  physiopathology
Thrombosis / physiopathology,  prevention & control*

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