Document Detail


Prenatal screening for cystic fibrosis: 5 years' experience reviewed.
MedLine Citation:
PMID:  8544548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although several programmes of prenatal screening for cystic fibrosis have been completed and reported, there are still uncertainties about rates of take up and also about the action of parents identified as having a one-in-four risk of an affected child. I report 5 years' experience with the two-step and couple models of prenatal screening of cystic fibrosis. METHODS: Screening has been available at two antenatal clinics in Edinburgh, UK, since January, 1992, first on a research basis and then routinely. 25,000 couples have been screened. FINDINGS: Take-up rates for the two-step and couple models of delivery are very similar at about 70%. Take-up rates did not change when screening moved from a research to a routine service. Of 22 high-risk couples identified entirely through screening, 20 (91%) opted for prenatal diagnosis. Four couples returned for second and two for third monitored pregnancies. In all eight cases where affected fetuses were identified, pregnancy was terminated. INTERPRETATION: These data remove one of the few remaining obstacles to a general implementation of prenatal screening for cystic fibrosis.
Authors:
D J Brock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  347     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-09     Completed Date:  1996-02-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  148-50     Citation Subset:  AIM; IM    
Affiliation:
Human Genetics Unit, University of Edinburgh, Western General Hospital, UK.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced
Cystic Fibrosis / diagnosis,  genetics*
Female
Fetal Diseases / diagnosis,  genetics
Genetic Testing* / utilization
Heterozygote
Humans
Male
Pregnancy
Prenatal Diagnosis* / utilization
Scotland
Comments/Corrections
Comment In:
Lancet. 1996 Apr 6;347(9006):969   [PMID:  8598778 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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