Document Detail

Prenatal screening for cystic fibrosis: 5 years' experience reviewed.
MedLine Citation:
PMID:  8544548     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although several programmes of prenatal screening for cystic fibrosis have been completed and reported, there are still uncertainties about rates of take up and also about the action of parents identified as having a one-in-four risk of an affected child. I report 5 years' experience with the two-step and couple models of prenatal screening of cystic fibrosis. METHODS: Screening has been available at two antenatal clinics in Edinburgh, UK, since January, 1992, first on a research basis and then routinely. 25,000 couples have been screened. FINDINGS: Take-up rates for the two-step and couple models of delivery are very similar at about 70%. Take-up rates did not change when screening moved from a research to a routine service. Of 22 high-risk couples identified entirely through screening, 20 (91%) opted for prenatal diagnosis. Four couples returned for second and two for third monitored pregnancies. In all eight cases where affected fetuses were identified, pregnancy was terminated. INTERPRETATION: These data remove one of the few remaining obstacles to a general implementation of prenatal screening for cystic fibrosis.
D J Brock
Related Documents :
9360508 - Evaluation of the dexamethasone suppression test for the diagnosis of glucocorticoid-re...
12593898 - Parallel observation of four methods for screening women under 25 years of age for geni...
1579878 - School screening for scoliosis: methodologic considerations. part 1: external measureme...
9166168 - Down syndrome and neural tube defect screening: the value of using gestational age by u...
6201018 - The development of the sweat and sebaceous glands in the skin of the one-humped camel (...
19003798 - First trimester maternal serum papp-a, beta-hcg and adam12 in prediction of small-for-g...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  347     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-09     Completed Date:  1996-02-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  148-50     Citation Subset:  AIM; IM    
Human Genetics Unit, University of Edinburgh, Western General Hospital, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abortion, Induced
Cystic Fibrosis / diagnosis,  genetics*
Fetal Diseases / diagnosis,  genetics
Genetic Testing* / utilization
Prenatal Diagnosis* / utilization
Comment In:
Lancet. 1996 Apr 6;347(9006):969   [PMID:  8598778 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Randomised trial of oral morphine for chronic non-cancer pain.
Next Document:  Psychometric scores and persistence of irritable bowel after infectious diarrhoea.