Document Detail

Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network.
MedLine Citation:
PMID:  15805375     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify prenatal and perinatal risk factors for clinically severe (stage 3 or 4) retinopathy of prematurity (ROP). METHODS: Data were collected prospectively as part of the ongoing Australian and New Zealand Neonatal Network audit of high-risk infants (birth weight of <1500 g or gestational age [GA] of <32 weeks) admitted to a level III neonatal unit in Australia or New Zealand. Prenatal and perinatal factors to 1 minute of age were examined for the subset of infants with GA of <29 weeks who survived to 36 weeks' postmenstrual age and were examined for ROP (n = 2105). The factors significantly associated with stage 3 or 4 ROP were entered into a multivariate logistic regression model. RESULTS: Two-hundred three infants (9.6%) had stage 3 or more ROP. Prematurity was the dominant risk factor, with infants with GA of <25 weeks having 20 times greater odds of severe ROP than infants with GA of 28 weeks. Birth weight for GA also had a "dose-response" effect; the more growth-restricted infants had greater risk, with infants below the 3rd percentile of weight for GA having 4 times greater odds of severe ROP than those between the 25th and 75th percentiles. Male gender was also a significant risk factor (odds ratio: 1.73; 95% confidence interval: 1.25-2.40). CONCLUSIONS: These data, for a large, essentially population-based cohort, suggest that factors related to the degree of immaturity, intrauterine growth restriction, and male gender contribute to severe ROP.
Brian A Darlow; Jolie L Hutchinson; David J Henderson-Smart; Deborah A Donoghue; Judy M Simpson; Nicholas J Evans;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  115     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  990-6     Citation Subset:  AIM; IM    
Department of Paediatrics, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand.
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MeSH Terms
Birth Weight
Cohort Studies
Fetal Growth Retardation / complications
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Small for Gestational Age
Infant, Very Low Birth Weight*
New Zealand
ROC Curve
Retinopathy of Prematurity / etiology*
Risk Factors
Comment In:
Pediatrics. 2005 Aug;116(2):516; author reply 516-7   [PMID:  16061614 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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