Document Detail


Prenatal risk factors for autism: comprehensive meta-analysis.
MedLine Citation:
PMID:  19567888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aetiology of autism is unknown, although prenatal exposures have been the focus of epidemiological research for over 40 years.
AIMS: To provide the first quantitative review and meta-analysis of the association between maternal pregnancy complications and pregnancy-related factors and risk of autism.
METHOD: PubMed, Embase and PsycINFO databases were searched for epidemiological studies that examined the association between pregnancy-related factors and autism. Forty studies were eligible for inclusion in the meta-analysis. Summary effect estimates were calculated for factors examined in multiple studies.
RESULTS: Over 50 prenatal factors have been examined. The factors associated with autism risk in the meta-analysis were advanced parental age at birth, maternal prenatal medication use, bleeding, gestational diabetes, being first born v. third or later, and having a mother born abroad. The factors with the strongest evidence against a role in autism risk included previous fetal loss and maternal hypertension, proteinuria, pre-eclampsia and swelling.
CONCLUSIONS: There is insufficient evidence to implicate any one prenatal factor in autism aetiology, although there is some evidence to suggest that exposure to pregnancy complications may increase the risk.
Authors:
Hannah Gardener; Donna Spiegelman; Stephen L Buka
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  195     ISSN:  1472-1465     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-12-11     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-14     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Miami Miller School of Medicine, Post Office Box 016960 (M712), Miami, FL 33101, USA. hgardener@med.miami.edu
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MeSH Terms
Descriptor/Qualifier:
Autistic Disorder / etiology*
Birth Order
Diabetes, Gestational
Emigration and Immigration
Female
Fetal Hypoxia
Humans
Parents
Pregnancy
Pregnancy Complications*
Prevalence
Regression Analysis
Risk Factors
Grant Support
ID/Acronym/Agency:
T32 MH017119/MH/NIMH NIH HHS; T32 MH17119/MH/NIMH NIH HHS
Comments/Corrections
Comment In:
Br J Psychiatry. 2010 May;196(5):416; author reply 416-7   [PMID:  20435973 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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