Document Detail

Prenatal risk factors for autism: comprehensive meta-analysis.
MedLine Citation:
PMID:  19567888     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aetiology of autism is unknown, although prenatal exposures have been the focus of epidemiological research for over 40 years.
AIMS: To provide the first quantitative review and meta-analysis of the association between maternal pregnancy complications and pregnancy-related factors and risk of autism.
METHOD: PubMed, Embase and PsycINFO databases were searched for epidemiological studies that examined the association between pregnancy-related factors and autism. Forty studies were eligible for inclusion in the meta-analysis. Summary effect estimates were calculated for factors examined in multiple studies.
RESULTS: Over 50 prenatal factors have been examined. The factors associated with autism risk in the meta-analysis were advanced parental age at birth, maternal prenatal medication use, bleeding, gestational diabetes, being first born v. third or later, and having a mother born abroad. The factors with the strongest evidence against a role in autism risk included previous fetal loss and maternal hypertension, proteinuria, pre-eclampsia and swelling.
CONCLUSIONS: There is insufficient evidence to implicate any one prenatal factor in autism aetiology, although there is some evidence to suggest that exposure to pregnancy complications may increase the risk.
Hannah Gardener; Donna Spiegelman; Stephen L Buka
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  195     ISSN:  1472-1465     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-12-11     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-14     Citation Subset:  IM    
Department of Neurology, University of Miami Miller School of Medicine, Post Office Box 016960 (M712), Miami, FL 33101, USA.
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MeSH Terms
Autistic Disorder / etiology*
Birth Order
Diabetes, Gestational
Emigration and Immigration
Fetal Hypoxia
Pregnancy Complications*
Regression Analysis
Risk Factors
Grant Support
Comment In:
Br J Psychiatry. 2010 May;196(5):416; author reply 416-7   [PMID:  20435973 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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