| Prenatal psychobiological predictors of anxiety risk in preadolescent children. | |
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MedLine Citation:
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PMID: 22265195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental animal models have demonstrated that one of the primary consequences of prenatal stress is increased fear and anxiety in the offspring. Few prospective human studies have evaluated the consequences of prenatal stress on anxiety during preadolescence. The purpose of this investigation is to determine the consequences of prenatal exposure to both maternal biological stress signals and psychological distress on anxiety in preadolescent children. Participants included 178 mother-child pairs. Maternal psychological distress (general anxiety, perceived stress, depression and pregnancy-specific anxiety) and biological stress signals were evaluated at 19, 25, and 31 gestational weeks. Anxiety was evaluated in the children at 6-9 years of age using the Child Behavior Checklist. Analyses revealed that prenatal exposure to elevated maternal cortisol, depression, perceived stress and pregnancy-specific anxiety was associated with increased anxiety in children. These associations remained after considering obstetric, sociodemographic and postnatal maternal psychological distress; factors that could influence child development. When all of the prenatal measures were considered together, cortisol and pregnancy-specific anxiety independently predicted child anxiety. Children exposed to elevated prenatal maternal cortisol and pregnancy-specific anxiety were at an increased risk for developing anxiety problems during the preadolescent period. This project identifies prenatal risk factors associated with lasting consequences for child mental health and raises the possibility that reducing maternal distress during the prenatal period will have long term benefits for child well-being. |
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Authors:
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Elysia Poggi Davis; Curt A Sandman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-01-20 |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 37 ISSN: 1873-3360 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-06-18 Completed Date: 2012-11-05 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 1224-33 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Women and Children's Health and Well-Being Project, Department of Psychiatry & Human Behavior, University of California, Irvine, Orange, CA 92868, USA. edavis@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anxiety Disorders / diagnosis*, epidemiology, etiology*, metabolism Child Female Humans Hydrocortisone / metabolism Longitudinal Studies Male Maternal-Fetal Relations / psychology Mothers / psychology Pregnancy Pregnancy Complications / metabolism, psychology Prenatal Exposure Delayed Effects / epidemiology, metabolism, psychology* Prognosis Risk Factors Saliva / metabolism Stress, Psychological / complications, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD-28413/HD/NICHD NIH HHS; HD-50662/HD/NICHD NIH HHS; HD-51852/HD/NICHD NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 HD028413/HD/NICHD NIH HHS; R01 HD028413-06/HD/NICHD NIH HHS; R01 HD050662/HD/NICHD NIH HHS; R01 HD050662-01A1/HD/NICHD NIH HHS; R01 HD051852/HD/NICHD NIH HHS; R01 HD051852-01A1/HD/NICHD NIH HHS; R01 NS041298/NS/NINDS NIH HHS; R01 NS041298-01A1/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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