Document Detail


Prenatal psychobiological predictors of anxiety risk in preadolescent children.
MedLine Citation:
PMID:  22265195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental animal models have demonstrated that one of the primary consequences of prenatal stress is increased fear and anxiety in the offspring. Few prospective human studies have evaluated the consequences of prenatal stress on anxiety during preadolescence. The purpose of this investigation is to determine the consequences of prenatal exposure to both maternal biological stress signals and psychological distress on anxiety in preadolescent children. Participants included 178 mother-child pairs. Maternal psychological distress (general anxiety, perceived stress, depression and pregnancy-specific anxiety) and biological stress signals were evaluated at 19, 25, and 31 gestational weeks. Anxiety was evaluated in the children at 6-9 years of age using the Child Behavior Checklist. Analyses revealed that prenatal exposure to elevated maternal cortisol, depression, perceived stress and pregnancy-specific anxiety was associated with increased anxiety in children. These associations remained after considering obstetric, sociodemographic and postnatal maternal psychological distress; factors that could influence child development. When all of the prenatal measures were considered together, cortisol and pregnancy-specific anxiety independently predicted child anxiety. Children exposed to elevated prenatal maternal cortisol and pregnancy-specific anxiety were at an increased risk for developing anxiety problems during the preadolescent period. This project identifies prenatal risk factors associated with lasting consequences for child mental health and raises the possibility that reducing maternal distress during the prenatal period will have long term benefits for child well-being.
Authors:
Elysia Poggi Davis; Curt A Sandman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-20
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  37     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-11-05     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1224-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety Disorders / diagnosis*,  epidemiology,  etiology*,  metabolism
Child
Female
Humans
Hydrocortisone / metabolism
Longitudinal Studies
Male
Maternal-Fetal Relations / psychology
Mothers / psychology
Pregnancy
Pregnancy Complications / metabolism,  psychology
Prenatal Exposure Delayed Effects / epidemiology,  metabolism,  psychology*
Prognosis
Risk Factors
Saliva / metabolism
Stress, Psychological / complications,  metabolism
Grant Support
ID/Acronym/Agency:
HD-28413/HD/NICHD NIH HHS; HD-50662/HD/NICHD NIH HHS; HD-51852/HD/NICHD NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 HD028413/HD/NICHD NIH HHS; R01 HD028413-06/HD/NICHD NIH HHS; R01 HD050662/HD/NICHD NIH HHS; R01 HD050662-01A1/HD/NICHD NIH HHS; R01 HD051852/HD/NICHD NIH HHS; R01 HD051852-01A1/HD/NICHD NIH HHS; R01 NS041298/NS/NINDS NIH HHS; R01 NS041298-01A1/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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