Document Detail

Prenatal protein restriction leads to a disparity between aortic and peripheral blood pressure in Wistar male offspring.
MedLine Citation:
PMID:  20693295     Owner:  NLM     Status:  MEDLINE    
A host of animal studies have been used to model the effects of exposure to a low protein diet in utero on adult blood pressure. Collection of systolic blood pressure data by the indirect tail-cuff plethysmography method consistently shows increased pressures in low protein exposed rodent offspring compared to controls, but this technique has been criticised as the associated stress artefacts may confound the observed effects. Conversely, radiotelemetry systems allow unrestrained and continuous monitoring of blood pressure through the awake and sleep phases of the diurnal cycle. In this novel study, we directly compared blood pressure parameters in male offspring from low protein and control-fed dams measured simultaneously using tail-cuff and radiotelemetry systems. Control rats showed a good correlation between tail-cuff and radiotelemetry derived blood pressure data. Conversely, low protein males were relatively hypertensive at 8 weeks of age when measured by tail-cuff, but had significantly lower blood pressure than controls at 12 weeks of age when measured by telemetry. Heart rate and length of systole did not differ between the two groups. Individual stress protocols mimicking those imposed by tail-cuff plethysmography (novel environment, heat, restraint, inflation), caused similar increases in blood pressure and heart rate in control and low protein animals, ruling out an effect of enhanced pressor response to stress following prenatal protein restriction. Instead, an increase in peripheral vascular resistance in these animals is considered possible. Such a disparity between central and peripheral blood pressure measurements could have important clinical implications regarding cardiovascular risk assessment and treatment.
Angelina Swali; Sarah McMullen; Simon C Langley-Evans
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-06
Journal Detail:
Title:  The Journal of physiology     Volume:  588     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-21     Revised Date:  2012-04-27    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3809-18     Citation Subset:  IM    
School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK.
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MeSH Terms
Aorta / physiology
Blood Pressure / physiology*
Diet, Protein-Restricted / adverse effects*
Electrodes, Implanted
Heart / physiology*
Prenatal Exposure Delayed Effects / physiopathology*
Rats, Wistar
Regional Blood Flow / physiology
Stress, Psychological / physiopathology
Grant Support
//Biotechnology and Biological Sciences Research Council; //British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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