Document Detail

Prenatal prediction of neonatal morbidity in survivors with congenital diaphragmatic hernia: a multicenter study.
MedLine Citation:
PMID:  18844275     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the value of the observed to expected fetal lung area to head circumference ratio (o/e LHR) and liver position in the prediction of neonatal morbidity in survivors with congenital diaphragmatic hernia (CDH). METHODS: Neonatal morbidity was recorded in 100 consecutive cases with isolated CDH diagnosed in fetal medicine units, which were expectantly managed in the prenatal period, were delivered after 30 weeks and survived until discharge from hospital. Regression analysis was used to identify the significant predictors of morbidity, including prenatal and immediate neonatal findings. RESULTS: The o/e LHR provided significant prediction of the need for prosthetic patch repair, duration of assisted ventilation, need for supplemental oxygen at 28 days, and incidence of feeding problems. An additional independent prenatal predictor of the need for patch repair was the presence of fetal liver in the chest. CONCLUSIONS: In isolated CDH the prenatally assessed size of the contralateral lung is a significant predictor of the need for prosthetic patch repair, the functional consequences of impaired lung development and occurrence of feeding problems.
J C Jani; A Benachi; K H Nicolaides; K Allegaert; E Gratacós; R Mazkereth; J Matis; D Tibboel; A Van Heijst; L Storme; V Rousseau; A Greenough; J A Deprest;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  33     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 ISUOG.
Fetal Medicine and Treatment Unit of King's College Hospital, London, UK.
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MeSH Terms
Feeding Behavior
Gestational Age
Head / embryology,  ultrasonography*
Hernia, Diaphragmatic / congenital,  surgery,  ultrasonography*
Infant, Newborn
Liver / embryology,  surgery,  ultrasonography*
Lung / embryology,  surgery,  ultrasonography*
Lung Volume Measurements
Pregnancy Trimester, Third
Ultrasonography, Prenatal / methods
D Van Schoubroeck / ; O Moreno / ; J Laudy / ; V Eisenberg / ; R Favre / ; A Eggink / ; P Vaast /

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