| Prenatal and postnatal cocaine exposure predict teen cocaine use. | |
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MedLine Citation:
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PMID: 20609384 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Preclinical studies have identified alterations in cocaine and alcohol self-administration and behavioral responses to pharmacological challenges in adolescent offspring following prenatal exposure. To date, no published human studies have evaluated the relation between prenatal cocaine exposure and postnatal adolescent cocaine use. Human studies of prenatal cocaine-exposed children have also noted an increase in behaviors previously associated with substance use/abuse in teens and young adults, specifically childhood and teen externalizing behaviors, impulsivity, and attention problems. Despite these findings, human research has not addressed prior prenatal exposure as a potential predictor of teen drug use behavior. The purpose of this study was to evaluate the relations between prenatal cocaine exposure and teen cocaine use in a prospective longitudinal cohort (n=316) that permitted extensive control for child, parent and community risk factors. Logistic regression analyses and Structural Equation Modeling revealed that both prenatal exposure and postnatal parent/caregiver cocaine use were uniquely related to teen use of cocaine at age 14years. Teen cocaine use was also directly predicted by teen community violence exposure and caregiver negativity, and was indirectly related to teen community drug exposure. These data provide further evidence of the importance of prenatal exposure, family and community factors in the intergenerational transmission of teen/young adult substance abuse/use. |
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Authors:
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Virginia Delaney-Black; Lisa M Chiodo; John H Hannigan; Mark K Greenwald; James Janisse; Grace Patterson; Marilyn A Huestis; Robert T Partridge; Joel Ager; Robert J Sokol |
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Publication Detail:
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Type: Journal Article Date: 2010-07-06 |
Journal Detail:
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Title: Neurotoxicology and teratology Volume: 33 ISSN: 1872-9738 ISO Abbreviation: Neurotoxicol Teratol Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709538 Medline TA: Neurotoxicol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 110-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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The Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan, 48201, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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