Document Detail

Prenatal, perinatal, and postnatal risk factors in obsessive-compulsive disorder.
MedLine Citation:
PMID:  17123475     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The etiology of obsessive-compulsive disorder (OCD) remains unknown, although it is thought to involve an interaction of genetic and environmental factors. This study aimed to identify prenatal, perinatal, and postnatal risk factors in OCD. METHODS: We compared retrospectively 68 OCD patients to 70 control subjects based on responses given on a standardized questionnaire. The questionnaire was designed to evaluate environmental factors, with a special focus on gestation, labor, birth, and early infancy aspects. RESULTS: The group of OCD patients had risk factors with greater frequency than the control group. Notable among the significant findings (p < or = 0.001) were edema of the hands, feet, or face and excessive weight gain during gestation; hyperemesis gravidarum; prolonged labor; preterm birth; and jaundice. When socioeconomic class was used as a covariable in the logistic regression analysis, prolonged labor and edema during pregnancy remained statistically significant. CONCLUSIONS: Some early risk factors may be associated with the expression of OCD later in life such as edema during pregnancy and prolonged labor. If our findings are confirmed in future studies, greater attention should be given to such factors in predisposed individuals, especially in prenatal care and delivery.
Marcos Salem Vasconcelos; Aline Santos Sampaio; Ana Gabriela Hounie; Fernando Akkerman; Mariana Curi; Antonio Carlos Lopes; Euripedes C Miguel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-21
Journal Detail:
Title:  Biological psychiatry     Volume:  61     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
Department of Psychiatry, University of São Paulo Medical School, OCD Spectrum Disorders Program(PROTOC), São Paulo, Brazil.
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MeSH Terms
Edema / complications,  epidemiology
Infant, Newborn
Jaundice, Neonatal / epidemiology
Logistic Models
Obsessive-Compulsive Disorder / epidemiology*
Obstetric Labor Complications / epidemiology
Pregnancy Complications / epidemiology,  psychology
Retrospective Studies
Risk Factors
Weight Gain / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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