| Prenatal and perinatal low level lead exposure alters brainstem auditory evoked responses in infants. | |
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MedLine Citation:
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PMID: 7854608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wave III latency and the III-V interpeak interval of brainstem auditory evoked responses in infants in the first weeks of life decreased and increased, respectively, in association with mid-pregnancy maternal blood lead levels (2.5-35 micrograms/dl) in a group of 30 prospectively followed healthy pregnancies and deliveries. The rapid myelination of brainstem auditory pathways occurring around mid-pregnancy and the lengthening of the III-V interpeak interval with increased mid-pregnancy maternal lead suggest that brain structures involved in spatial localization of sound may be compromised by prenatal lead exposure. The data also indicate that maternal blood lead measurements during pregnancy provide an adequate surrogate index of fetal exposure. |
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Authors:
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S J Rothenberg; A Poblano; S Garza-Morales |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Neurotoxicology Volume: 15 ISSN: 0161-813X ISO Abbreviation: Neurotoxicology Publication Date: 1994 |
Date Detail:
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Created Date: 1995-03-16 Completed Date: 1995-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 695-9 Citation Subset: IM |
Affiliation:
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Department of Developmental Neurobiology, National Institute of Perinatology, México, DF, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Evoked Potentials, Auditory, Brain Stem / drug effects* Female Fetus / drug effects* Gestational Age Humans Infant, Newborn Lead / adverse effects*, blood Pregnancy |
| Chemical | |
Reg. No./Substance:
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7439-92-1/Lead |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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