| Prenatal and perinatal complications: is it the link between race and SES and childhood sleep disordered breathing? | |
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MedLine Citation:
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PMID: 20572420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: Recent evidence has suggested that low socioeconomic status (SES), race, prematurity, and maternal smoking during pregnancy are associated with childhood sleep disordered breathing (SDB). We investigated (1) the association of SDB with a wide range of risk factors, including prenatal and perinatal complications; (2) the association of these complications with SES and race; and (3) the association of SDB with developmental milestones. METHODS: Six hundred thirteen school-aged children (105 clinically referred and 508 community control subjects) underwent overnight polysomnography and had a complete history and physical examination. A comprehensive child development questionnaire was completed by a parent. We compared clinically referred children with SDB to population-based control children without SDB from The Penn State Children's Cohort. RESULTS: Maternal smoking during pregnancy; maternal age and weight gain during pregnancy; prenatal complications, such as maternal high blood pressure and gestational diabetes; perinatal complications related to prematurity; delayed motor milestones; race and SES were significantly associated with the presence of childhood SDB. Most of the risk factors became nonsignificant when analyses controlled for race and SES. Delayed motor milestones remained significantly associated with SDB after controlling for race and SES. CONCLUSION: These data suggest that there is a significant association between children who experience prenatal or perinatal distress and the development of moderate to severe childhood SDB. SES and race may be mediating the impact on SDB through increased prenatal and perinatal risks. The significant delay in motor milestones suggests that prenatal and perinatal distress may result in neurologic insult, which could influence the development of SDB in later childhood. |
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Authors:
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Susan L Calhoun; Alexandros N Vgontzas; Susan D Mayes; Marina Tsaoussoglou; Katherine Sauder; Fauzia Mahr; Anoop Karippot; Krista Wisner; Edward O Bixler |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine Volume: 6 ISSN: 1550-9389 ISO Abbreviation: J Clin Sleep Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-07-26 Revised Date: 2010-12-16 |
Medline Journal Info:
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Nlm Unique ID: 101231977 Medline TA: J Clin Sleep Med Country: United States |
Other Details:
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Languages: eng Pagination: 264-9 Citation Subset: IM |
Affiliation:
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Sleep Research and Treatment Center, Penn State University, College of Medicine, Hershey, PA, USA. scalhoun@psu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Causality Child Child Development Child, Preschool Cohort Studies Continental Population Groups / statistics & numerical data* Female Humans Infant, Newborn Infant, Premature, Diseases / epidemiology, therapy Intensive Care, Neonatal / methods, statistics & numerical data Male Mothers Odds Ratio Oxygen Inhalation Therapy / methods, statistics & numerical data Pennsylvania / epidemiology Polysomnography / methods Pregnancy Pregnancy Complications / epidemiology* Premature Birth / epidemiology* Prenatal Exposure Delayed Effects / epidemiology* Questionnaires Risk Factors Sleep Apnea Syndromes / epidemiology* Smoking / epidemiology Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR016499/RR/NCRR NIH HHS; R01 HL063772/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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