Document Detail

Prenatal origins of asthma and allergy.
MedLine Citation:
PMID:  9257015     Owner:  NLM     Status:  MEDLINE    
The prevalence of asthma and related allergic disorders has increased considerably over the last 25 years. Genetic stock has not changed, so environmental factors must have influenced the phenotype. Infants who develop allergy already have an altered immune response at birth. We have investigated the development of immune responses during gestation and the effect of maternal allergen exposure during pregnancy and infant exposure in the first month of life on the development of allergy and disease. There was higher specific peripheral blood mononuclear cell proliferation to house dust mite (P = 0.01) and birch pollen (P = 0.004) in the third trimester compared with the second trimester, with the first positive responses seen at 22 weeks gestation. Maternal exposure to birch pollen after 22 weeks resulted in higher (P = 0.005) infant peripheral blood mononuclear cell responses to birch pollen at birth. Infants born at term, with at least one atopic, asthmatic parent, who developed allergic symptoms and positive skin prick test by one year of age had raised proliferative responses to house dust mites at birth compared to those with no symptoms (P = 0.01). In genetically predisposed individuals, antenatal factors, including maternal and thereby fetal exposure to allergens and maternoplacental-fetal immunological interactions, are active in determining whether an allergic predisposition is manifested as disease.
J A Warner; A C Jones; E A Miles; B M Colwell; J O Warner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  206     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-15     Completed Date:  1997-10-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  220-8; discussion 228-32     Citation Subset:  IM    
Department of Child Health, University of Southampton, Southampton General Hospital, UK.
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MeSH Terms
Allergens / immunology
Asthma / immunology*
Cytokines / immunology
Hypersensitivity / immunology*
Immunity, Maternally-Acquired / immunology
Prenatal Exposure Delayed Effects*
T-Lymphocytes / immunology
Reg. No./Substance:
0/Allergens; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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