Document Detail

Prenatal nicotine alters maturation of breathing and neural circuits regulating respiratory control.
MedLine Citation:
PMID:  18455969     Owner:  NLM     Status:  MEDLINE    
While perinatal nicotine effects on ventilation have been widely investigated, the prenatal impact of nicotine treatment during gestation on both breathing and neural circuits involved in respiratory control remains unknown. We examined the effects of nicotine, from embryonic day 5 (E5) to E20, on baseline ventilation, the two hypoxic ventilatory response components and in vivo tyrosine hydroxylase (TH) activity in carotid bodies and brainstem areas, assessed at postnatal day 7 (P7), P11 and P21. In pups prenatally exposed to nicotine, baseline ventilation and hypoxic ventilatory response were increased at P7 (+48%) and P11 (+46%), with increased tidal volume (p<0.05). Hypoxia blunted frequency response at P7 and revealed unstable ventilation at P11. In carotid bodies, TH activity increased by 20% at P7 and decreased by 48% at P11 (p<0.05). In most brainstem areas it was reduced by 20-33% until P11. Changes were resolved by P21. Prenatal nicotine led to postnatal ventilatory sequelae, partly resulting from impaired maturation of peripheral chemoreceptors and brainstem integrative sites.
Sophie Mahlière; David Perrin; Julie Peyronnet; Aurélien Boussouar; Guy Annat; Jean-Paul Viale; Jacqueline Pequignot; Jean-Marc Pequignot; Yvette Dalmaz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-28
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  162     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  32-40     Citation Subset:  IM    
Université de Lyon, Lyon, France.
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MeSH Terms
Age Factors
Animals, Newborn
Anoxia / physiopathology
Brain Chemistry / drug effects
Chromatography, High Pressure Liquid
Embryo, Mammalian
Levodopa / metabolism
Nicotine / pharmacology*
Nicotinic Agonists / pharmacology*
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Respiration / drug effects*
Respiratory System* / drug effects,  embryology,  growth & development
Tidal Volume / drug effects,  physiology
Tyrosine 3-Monooxygenase / metabolism
Reg. No./Substance:
0/Levodopa; 0/Nicotinic Agonists; 54-11-5/Nicotine; EC 3-Monooxygenase

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