| Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. | |
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MedLine Citation:
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PMID: 12767734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Exposure to methylmercury (MeHg) before birth can adversely affect children's neurodevelopment. The most common form of prenatal exposure is maternal fish consumption, but whether such exposure harms the fetus is unknown. We aimed to identify adverse neurodevelopmental effects in a fish-consuming population. METHODS: We investigated 779 mother-infant pairs residing in the Republic of Seychelles. Mothers reported consuming fish on average 12 meals per week. Fish in Seychelles contain much the same concentrations of MeHg as commercial ocean fish elsewhere. Prenatal MeHg exposure was determined from maternal hair growing during pregnancy. We assessed neurocognitive, language, memory, motor, perceptual-motor, and behavioural functions in children at age 9 years. The association between prenatal MeHg exposure and the primary endpoints was investigated with multiple linear regression with adjustment for covariates that affect child development. FINDINGS: Mean prenatal MeHg exposure was 6.9 parts per million (SD 4.5 ppm). Only two endpoints were associated with prenatal MeHg exposure. Increased exposure was associated with decreased performance in the grooved pegboard using the non-dominant hand in males and improved scores in the hyperactivity index of the Conner's teacher rating scale. Covariates affecting child development were appropriately associated with endpoints. INTERPRETATION: These data do not support the hypothesis that there is a neurodevelopmental risk from prenatal MeHg exposure resulting solely from ocean fish consumption. |
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Authors:
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Gary J Myers; Philip W Davidson; Christopher Cox; Conrad F Shamlaye; Donna Palumbo; Elsa Cernichiari; Jean Sloane-Reeves; Gregory E Wilding; James Kost; Li-Shan Huang; Thomas W Clarkson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lancet Volume: 361 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-27 Completed Date: 2003-06-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 1686-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, National Institute for Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, USA. gary_myers@urmc.rochester.edu <gary_myers@urmc.rochester.edu> |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Child Cognition Disorders / chemically induced, diagnosis, epidemiology Cohort Studies Comorbidity Environmental Exposure / analysis* Female Fishes Follow-Up Studies Food Contamination / analysis* Hair / chemistry Humans Infant Mercury Poisoning / epidemiology Methylmercury Compounds / adverse effects, analysis* Pregnancy Prenatal Exposure Delayed Effects* Regression Analysis Seafood* Seychelles / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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ES-01247/ES/NIEHS NIH HHS; R01-08442//PHS HHS; R01-ES10219/ES/NIEHS NIH HHS; T32 ES-007/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methylmercury Compounds |
| Comments/Corrections | |
Comment In:
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Lancet. 2003 Aug 23;362(9384):664-5; author reply 665
[PMID:
12944071
]
Lancet. 2003 May 17;361(9370):1667-8 [PMID: 12767728 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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