Document Detail


Prenatal methylazoxymethanol exposure alters evoked responses in fetal rats.
MedLine Citation:
PMID:  15315815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although there is considerable interest in identifying methods to detect central nervous system impairment early in development, few behavioral assessment tools are available for detecting CNS deficits in the fetus. In the present study, methylazoxymethanol [MAM; Midwest Research Institute, (MRI)] was used to induce deficits in CNS development in fetal rats to assess effects on coordinated fetal behavior. Fetuses were exposed by administering MAM to pregnant rats on E17 of gestation via intraperitoneal injection and then were prepared for behavioral testing 3 days later on E20. After externalization from the uterus into a warm saline bath, fetal subjects received either an intraoral infusion of lemon extract to evoke a facial wiping response or were presented with an artificial nipple to evoke an oral grasping response. Interlimb coordination and paw-face contact during facial wiping were disrupted in MAM-exposed fetuses. Similarly, MAM exposure diminished the ability of fetuses to grasp or maintain oral contact with the artificial nipple. Although clear disruptions of movement coordination were seen in the MAM-treated subjects, there were no significant differences from saline controls in weight or anatomical measures. Together, these findings suggest that behavioral assessments of fetal motor coordination may be useful in identifying neural insult during prenatal development.
Authors:
Gale A Kleven; Laila Queral; Scott R Robinson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  26     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2004 Sep-Oct
Date Detail:
Created Date:  2004-08-18     Completed Date:  2004-11-09     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  663-71     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA. gale-kleven@uiowa.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal / drug effects
Central Nervous System Diseases / chemically induced*
Dose-Response Relationship, Drug
Embryo, Mammalian / drug effects,  physiopathology
Face / physiology
Female
Injections, Intraperitoneal
Male
Methylazoxymethanol Acetate / analogs & derivatives*,  toxicity*
Mouth / drug effects,  physiology
Movement / drug effects*
Physical Stimulation
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Rats, Sprague-Dawley
Reaction Time / drug effects
Teratogens / toxicity*
Chemical
Reg. No./Substance:
0/Teratogens; 590-96-5/methylazoxymethanol; 592-62-1/Methylazoxymethanol Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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