Document Detail

Prenatal methamphetamine exposure and neonatal neurobehavioral outcome in the USA and New Zealand.
MedLine Citation:
PMID:  20615464     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Methamphetamine (MA) use among pregnant women is a world-wide problem, but little is known of its impact on exposed infants.
DESIGN: The prospective, controlled longitudinal Infant Development, Environment and Lifestyle (IDEAL) study of prenatal MA exposure from birth to 36 months was conducted in the US and NZ. The US cohort has 183 exposed and 196 comparison infants; the NZ cohort has 85 exposed and 95 comparison infants. Exposure was determined by self-report and meconium assay with alcohol, marijuana, and tobacco exposures present in both groups. The NICU Neurobehavior Scale (NNNS) was administered within 5 days of life. NNNS summary scores were analyzed for exposure including heavy exposure and frequency of use by trimester and dose-response relationship with the amphetamine analyte.
RESULTS: MA exposure was associated with poorer quality of movement, more total stress/abstinence, physiological stress, and CNS stress with more nonoptimal reflexes in NZ but not in the USA. Heavy MA exposure was associated with lower arousal and excitability. First trimester MA use predicted more stress and third trimester use more lethargy and hypotonicity. Dose-response effects were observed between amphetamine concentration in meconium and CNS stress.
CONCLUSION: Across cultures, prenatal MA exposure was associated with a similar neurobehavioral pattern of under arousal, low tone, poorer quality of movement and increased stress.
Linda L LaGasse; Trecia Wouldes; Elana Newman; Lynne M Smith; Rizwan Z Shah; Chris Derauf; Marilyn A Huestis; Amelia M Arria; Sheri Della Grotta; Tara Wilcox; Barry M Lester
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2010-07-06
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  33     ISSN:  1872-9738     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-01-24     Completed Date:  2011-05-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  166-75     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women & Infants Hospital, Providence, RI, USA.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Child Behavior / drug effects,  psychology
Child, Preschool
Follow-Up Studies
Infant Behavior / drug effects*,  psychology
Infant, Newborn
Maternal Exposure / adverse effects*
Methamphetamine / toxicity*
Neuropsychological Tests
New Zealand
Prenatal Exposure Delayed Effects / chemically induced,  epidemiology,  psychology*
Prospective Studies
United States
Grant Support
M01RR00426/RR/NCRR NIH HHS; P20RR11091/RR/NCRR NIH HHS; R01 DA014948-03/DA/NIDA NIH HHS; R01 DA014948-11/DA/NIDA NIH HHS; R01 DA021757-03/DA/NIDA NIH HHS; R01DA014948/DA/NIDA NIH HHS; R01DA021757/DA/NIDA NIH HHS; ZIA DA000433-11/DA/NIDA NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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