| Prenatal mercury contamination: relationship with maternal seafood consumption during pregnancy and fetal growth in the 'EDEN mother-child' cohort. | |
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MedLine Citation:
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PMID: 20487582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal seafood intake is of great health interest since it constitutes an important source of n-3 fatty acids, but provides also an important pathway for fetal exposure to Hg. The objective of the present study was to determine associations between Hg contamination and both maternal seafood consumption and fetal growth in French pregnant women. Pregnant women included in the 'EDEN mother-child' cohort study answered FFQ on their usual diet in the year before and during the last 3 months of pregnancy, from which frequencies of seafood intake were evaluated. Total hair-Hg level was determined for the first 691 included women. Associations between Hg level, seafood intake and several neonatal measurements were studied using linear regressions adjusted for confounding variables. The median Hg level for mothers was 0.52 μg/g. Maternal seafood intake was associated with Hg level (r 0.33; P < 0.0001). There was no association between Hg level and fetal growth in the whole sample of women, except for an early negative relationship with biparietal diameter. A positive association was found between seafood intake and fetal growth in overweight women only which remained unchanged after adjustment for Hg level (birth weight: +101 g for a difference of 1 sd in seafood consumption; P = 0.008). Although seafood intake was associated with Hg contamination in French pregnant women, the contamination level was low. There was no consistent association between Hg level and fetal growth. Taking into account Hg level did not modify associations between seafood intake and fetal growth. |
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Authors:
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Peggy Drouillet-Pinard; Guy Huel; R Slama; Anne Forhan; J Sahuquillo; Valérie Goua; Olivier Thiébaugeorges; Bernard Foliguet; Guillaume Magnin; Monique Kaminski; Sylvaine Cordier; Marie-Aline Charles |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-21 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-11-04 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1096-100 Citation Subset: IM |
Affiliation:
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INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Team Epidemiology of Obesity, Diabetes and Renal Disease over the Lifecourse, Villejuif, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cohort Studies Female Fetal Growth Retardation / chemically induced* Food Contamination Hair / chemistry Humans Infant, Newborn Male Mercury / analysis, toxicity* Pregnancy Prenatal Exposure Delayed Effects Seafood* Water Pollutants, Chemical / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Water Pollutants, Chemical; 7439-97-6/Mercury |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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