Document Detail

Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study.
MedLine Citation:
PMID:  17652957     Owner:  NLM     Status:  MEDLINE    
Recent evidence has shown that prenatal maternal stress has negative consequences for the mental health of the adult organism. Our aim was to examine the efficacy of using the selective serotonin reuptake inhibitor, paroxetine, to alleviate the symptoms of prenatal maternal stress in Fisher 344 rats. Pregnant rats were subjected to daily restraint stress and concurrent paroxetine treatment (10 mg/kg p.o.) during the last week of gestation. Maternal paroxetine treatment led to a shortened gestational length, reduced birth weight and a 10-fold rise in neonatal mortality in both stressed and non-stressed litters. These results reiterate the need for further research on the effects of paroxetine treatment during gestation.
Daniël L A Van den Hove; Carlos E Blanco; Arjan Scheepens; Lieve Desbonnet; Aye-Mu Myint; Brian E Leonard; Jos Prickaerts; Harry W M Steinbusch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-25
Journal Detail:
Title:  Neonatology     Volume:  93     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  52-5     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Department of Psychiatry and Neuropsychology, Research Institute Brain and Behavior, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands.
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MeSH Terms
Animals, Newborn
Paroxetine / adverse effects*,  therapeutic use
Prenatal Exposure Delayed Effects / chemically induced*,  mortality
Rats, Inbred F344
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Stress, Psychological / drug therapy
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 61869-08-7/Paroxetine

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