Document Detail

Prenatal maternal biochemistry predicts neonatal biochemistry.
MedLine Citation:
PMID:  15527200     Owner:  NLM     Status:  MEDLINE    
Depressed (n = 45) and nondepressed (n = 47) mothers were recruited prenatally at an ultrasound clinic. Their urine samples were assayed for cortisol, catecholamines (norepinephrine, epinephrine, dopamine) and serotonin. Their urines were assayed again at the neonatal period, and their newborns' urines were also assayed at that time. The depressed versus the nondepressed mothers showed significantly higher cortisol and norepinephrine and significantly lower dopamine levels across the pre- and postnatal assessments. At the postnatal assessment all levels had decreased except the serotonin levels for both groups. Regression analyses on the mother's postnatal biochemistry with the prenatal biochemistry entered as predictor variables showed highly significant, specific relationships between each of the catecholamines, cortisol, and serotonin. The newborn's biochemistry (except for epinephrine) was higher than the maternal biochemistry. Regression analyses on the neonatal biochemistry with the mother's prenatal biochemistry entered as predictor variables also suggested highly significant, specific relationships. The continuity between the mother's and the newborn's neurotransmitter/ neurohormone profiles and data showing that elevated norepinephrine and cortisol predict to low birthweight and prematurity, respectively, highlight the importance of assessing these levels during pregnancy.
Tiffany Field; Miguel Diego; Maria Hernandez-Reif; Yanexy Vera; Karla Gil; Saul Schanberg; Cynthia Kuhn; Adolfo Gonzalez-Garcia
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  114     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-11-05     Completed Date:  2005-01-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  933-45     Citation Subset:  IM    
Department of Pediatrics, Touch Research Institutes, University of Miami School of Medicine, Miami, Florida 33101, USA.
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MeSH Terms
Analysis of Variance
Biochemical Phenomena
Catecholamines / urine
Depression / urine*
Hydrocortisone / urine
Infant, Newborn / urine*
Maternal-Fetal Exchange*
Mothers / psychology*
Pregnancy / urine*
Reference Values
Regression Analysis
Serotonin / urine
Grant Support
Reg. No./Substance:
0/Catecholamines; 50-23-7/Hydrocortisone; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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