| Prenatal maternal biochemistry predicts neonatal biochemistry. | |
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MedLine Citation:
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PMID: 15527200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Depressed (n = 45) and nondepressed (n = 47) mothers were recruited prenatally at an ultrasound clinic. Their urine samples were assayed for cortisol, catecholamines (norepinephrine, epinephrine, dopamine) and serotonin. Their urines were assayed again at the neonatal period, and their newborns' urines were also assayed at that time. The depressed versus the nondepressed mothers showed significantly higher cortisol and norepinephrine and significantly lower dopamine levels across the pre- and postnatal assessments. At the postnatal assessment all levels had decreased except the serotonin levels for both groups. Regression analyses on the mother's postnatal biochemistry with the prenatal biochemistry entered as predictor variables showed highly significant, specific relationships between each of the catecholamines, cortisol, and serotonin. The newborn's biochemistry (except for epinephrine) was higher than the maternal biochemistry. Regression analyses on the neonatal biochemistry with the mother's prenatal biochemistry entered as predictor variables also suggested highly significant, specific relationships. The continuity between the mother's and the newborn's neurotransmitter/ neurohormone profiles and data showing that elevated norepinephrine and cortisol predict to low birthweight and prematurity, respectively, highlight the importance of assessing these levels during pregnancy. |
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Authors:
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Tiffany Field; Miguel Diego; Maria Hernandez-Reif; Yanexy Vera; Karla Gil; Saul Schanberg; Cynthia Kuhn; Adolfo Gonzalez-Garcia |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The International journal of neuroscience Volume: 114 ISSN: 0020-7454 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-11-05 Completed Date: 2005-01-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 933-45 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Touch Research Institutes, University of Miami School of Medicine, Miami, Florida 33101, USA. tfield@.med.miami.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Biochemical Phenomena Biochemistry Catecholamines / urine Depression / urine* Female Humans Hydrocortisone / urine Infant, Newborn / urine* Male Maternal-Fetal Exchange* Mothers / psychology* Pregnancy / urine* Reference Values Regression Analysis Serotonin / urine |
| Grant Support | |
ID/Acronym/Agency:
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MH 00331/MH/NIMH NIH HHS; MH 46586/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 50-23-7/Hydrocortisone; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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