Document Detail

Prenatal malnutrition-induced hypertension in young rats is prevented by neonatal capsaicin treatment.
MedLine Citation:
PMID:  12147319     Owner:  NLM     Status:  MEDLINE    
Prenatal malnutrition-induced fetal growth retardation in the rat results in elevated arterial blood pressure at adulthood. To test the contribution of cardiovascular sensory C fibers in the hypertensive state, arterial blood pressure was measured in prenatally undernourished rats treated at birth with capsaicin. The effects of the neonatal capsaicin treatment on heart rate and respiratory frequency were also evaluated. Maternal malnutrition resulted in body and brain weights deficits in the offspring that were not modified by neonatal capsaicin treatment. Capsaicin treatment did not change the cardiovascular parameters in normal rats, but prevented the elevation of arterial blood pressure and heart rate in malnourished animals. These results indicate that elevation of arterial blood pressure in prenatally malnourished rats depends on the activity of some sensory unmyelinated C fibers.
Hernán Pérez; Samuel Ruiz; Rubén Soto-Moyano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  328     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-30     Completed Date:  2002-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  253-6     Citation Subset:  IM    
Laboratory of Hormones and Receptors, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago, Chile.
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MeSH Terms
Animals, Newborn / physiology*
Capsaicin / therapeutic use*
Cardiovascular System / innervation
Fetal Growth Retardation / etiology
Heart Rate / drug effects
Hypertension / physiopathology,  prevention & control*
Nerve Fibers / physiology
Nutrition Disorders / complications,  embryology*
Pregnancy Complications
Rats, Sprague-Dawley
Respiration / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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