Document Detail


Prenatal malaria immune experience affects acquisition of Plasmodium falciparum merozoite surface protein-1 invasion inhibitory antibodies during infancy.
MedLine Citation:
PMID:  17082631     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
African infants are often born of mothers infected with malaria during pregnancy. This can result in fetal exposure to malaria-infected erythrocytes or their soluble products with subsequent fetal immune priming or tolerance in utero. We performed a cohort study of 30 newborns from a malaria holoendemic area of Kenya to determine whether T cell sensitization to Plasmodium falciparum merozoite surface protein-1 (MSP-1) at birth correlates with infant development of anti-MSP-1 Abs acquired as a consequence of natural malaria infection. Abs to the 42- and 19-kDa C-terminal processed fragments of MSP-1 were determined by serology and by a functional assay that quantifies invasion inhibition Abs against the MSP-1(19) merozoite ligand (MSP-1(19) IIA). Infants had detectable IgG and IgM Abs to MSP-1(42) and MSP-1(19) at 6 mo of age with no significant change by age 24-30 mo. In contrast, MSP-1(19) IIA levels increased from 6 to 24-30 mo of age (16-29%, p < 0.01). Infants with evidence of prenatal exposure to malaria (defined by P. falciparum detection in maternal, placental, and/or cord blood compartments) and T cell sensitization at birth (defined by cord blood lymphocyte cytokine responses to MSP-1) showed the greatest age-related increase in MSP-1(19) IIA compared with infants with prenatal exposure to malaria but who lacked detectable T cell MSP-1 sensitization. These data suggest that fetal sensitization or tolerance to MSP-1, associated with maternal malaria infection during pregnancy, affects the development of functional Ab responses to MSP-1 during infancy.
Authors:
Arlene Dent; Indu Malhotra; Peter Mungai; Eric Muchiri; Brendan S Crabb; James W Kazura; Christopher L King
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  177     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-03     Completed Date:  2007-01-05     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7139-45     Citation Subset:  AIM; IM    
Affiliation:
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Amino Acid Sequence
Animals
Antibodies, Protozoan / blood*
Child, Preschool
Cohort Studies
Female
Fetal Blood / cytology,  immunology,  metabolism
Humans
Infant
Malaria, Falciparum / immunology*,  parasitology
Merozoite Surface Protein 1 / genetics,  immunology*
Molecular Sequence Data
Plasmodium falciparum / immunology*
Pregnancy
Pregnancy Complications, Parasitic / immunology*,  parasitology
Prenatal Exposure Delayed Effects / immunology*,  parasitology*
Prospective Studies
Grant Support
ID/Acronym/Agency:
AI064687/AI/NIAID NIH HHS; AI0702427/AI/NIAID NIH HHS; AI45473/AI/NIAID NIH HHS; AI5206702/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Merozoite Surface Protein 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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