Document Detail

Prenatal low-level lead exposure and developmental delay of infants at age 6 months (Krakow inner city study).
MedLine Citation:
PMID:  17905657     Owner:  NLM     Status:  MEDLINE    
The purpose of the study was to assess the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy. Lead levels in the cord blood were used to assess environmental exposure and the Fagan Test of Infant Intelligence (FTII) assessed visual recognition memory (VRM). The cohort consisted of 452 infants of mothers who gave birth to babies at 33-42 weeks of gestation between January 2001 and March 2003. The overall mean lead level in the cord blood was 1.42 microg/dl (95% CI: 1.35-1.48). We found that VRM scores in 6 month olds were inversely related to lead cord blood levels (Spearman correlation coefficient -0.16, p=0.007). The infants scored lower by 1.5 points with an increase by one unit (1 microg/dl) of lead concentration in cord blood. In the lower exposed infants (1.67 microg/dl) the mean Fagan score was 61.0 (95% CI: 60.3-61.7) and that in the higher exposed group (>1.67 microg/dl) was 58.4 (95% CI: 57.3-59.7). The difference of 2.5 points was significant at the p=0.0005 level. The estimated risk of scoring the high-risk group of developmental delay (FTII classification 3) due to higher lead blood levels was two-fold greater (OR=2.33, 95% CI: 1.32-4.11) than for lower lead blood levels after adjusting for potential confounders (gestational age, gender of the child and maternal education). As the risk of the deficit in VRM score (Fagan group 3) in exposed infants attributable to Pb prenatal exposure was about 50%, a large portion of cases with developmental delay could be prevented by reducing maternal blood lead level below 1.67 microg/dl. Although the negative predictive value of the chosen screening criterion (above 1.67 microg/dl) was relatively high (89%) its positive predictive value was too low (22%), so that the screening program based on the chosen cord blood lead criterion was recommended.
Wieslaw Jedrychowski; Frederica Perera; Jeffery Jankowski; Virginia Rauh; Elzbieta Flak; Kathleen L Caldwell; Robert L Jones; Agnieszka Pac; Ilona Lisowska-Miszczyk
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-10-01
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  211     ISSN:  1438-4639     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2009-02-13     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
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MeSH Terms
Cognition / drug effects*
Developmental Disabilities / blood,  chemically induced,  epidemiology*
Environmental Exposure / adverse effects
Fetal Blood / chemistry
Infant, Newborn
Lead / adverse effects*,  blood
Linear Models
Maternal Exposure / adverse effects*
Memory / drug effects*
Neonatal Screening / methods
Poland / epidemiology
Prenatal Exposure Delayed Effects / blood,  epidemiology*
Prospective Studies
Psychological Tests
Young Adult
Grant Support
5 R01 ES10165/ES/NIEHS NIH HHS; R01 ES010165/ES/NIEHS NIH HHS; R01 ES010165-04/ES/NIEHS NIH HHS; R01 ES010165-0451/ES/NIEHS NIH HHS; R01 ES010165-04S1/ES/NIEHS NIH HHS
Reg. No./Substance:
Comment In:
Int J Hyg Environ Health. 2008 Oct;211(5-6):698   [PMID:  18460421 ]

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