Document Detail

Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid.
MedLine Citation:
PMID:  18211254     Owner:  NLM     Status:  MEDLINE    
This review addresses the effect of prenatal long-chain polyunsaturated fatty acid (LCPUFA) status on neurodevelopmental outcome. It focuses on the major LPCUFA doxosahexaenoic acid (DHA; 22:6omega3) and arachidonic acid (AA; 20:4omega6). Due to enzymatic competition high DHA intake results in lower tissue levels of AA. LCPUFA accumulation in the brain starts early and increases during the third trimester. Initially brain AA-accretion exceeds DHA-accretion; after term age DHA-accretion surpasses AA-accretion. Animal studies indicated that early omega3-depletion results in poorer developmental outcome. They also showed that early omega3-supplementation had no effect on cognitive outcome, promotes visual development and impairs auditory and motor development. Only limited human data are available. Correlational studies suggest that neonatal AA status shows a positive relation with early neurodevelopmental outcome and that neonatal DHA status also might be correlated with improved outcome beyond infancy. Results of human intervention studies are equivocal: most studies were unable to demonstrate a positive effect of prenatal omega3-supplementation. It is concluded that only limited evidence exists to support the notion that prenatal omega3-supplementation favours developmental outcome. Caution is warranted for an unbalanced high DHA intake during the first two trimesters of pregnancy, i.e., DHA without additional AA supplementation.
Mijna Hadders-Algra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  36     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-07-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  101-9     Citation Subset:  IM    
Department of Paediatrics - Developmental Neurology, University Medical Center Groningen, Groningen, The Netherlands.
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MeSH Terms
Arachidonic Acid / administration & dosage
Brain / growth & development*
Dietary Fats, Unsaturated / administration & dosage*
Dietary Supplements
Docosahexaenoic Acids / administration & dosage
Fatty Acids, Unsaturated / administration & dosage*
Prenatal Nutritional Physiological Phenomena*
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid
Comment In:
J Perinat Med. 2008;36(3):265-7; author reply 268-9   [PMID:  18576939 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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