| Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid. | |
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MedLine Citation:
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PMID: 18211254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review addresses the effect of prenatal long-chain polyunsaturated fatty acid (LCPUFA) status on neurodevelopmental outcome. It focuses on the major LPCUFA doxosahexaenoic acid (DHA; 22:6omega3) and arachidonic acid (AA; 20:4omega6). Due to enzymatic competition high DHA intake results in lower tissue levels of AA. LCPUFA accumulation in the brain starts early and increases during the third trimester. Initially brain AA-accretion exceeds DHA-accretion; after term age DHA-accretion surpasses AA-accretion. Animal studies indicated that early omega3-depletion results in poorer developmental outcome. They also showed that early omega3-supplementation had no effect on cognitive outcome, promotes visual development and impairs auditory and motor development. Only limited human data are available. Correlational studies suggest that neonatal AA status shows a positive relation with early neurodevelopmental outcome and that neonatal DHA status also might be correlated with improved outcome beyond infancy. Results of human intervention studies are equivocal: most studies were unable to demonstrate a positive effect of prenatal omega3-supplementation. It is concluded that only limited evidence exists to support the notion that prenatal omega3-supplementation favours developmental outcome. Caution is warranted for an unbalanced high DHA intake during the first two trimesters of pregnancy, i.e., DHA without additional AA supplementation. |
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Authors:
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Mijna Hadders-Algra |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 36 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2008 |
Date Detail:
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Created Date: 2008-03-11 Completed Date: 2008-07-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 101-9 Citation Subset: IM |
Affiliation:
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Department of Paediatrics - Developmental Neurology, University Medical Center Groningen, Groningen, The Netherlands. m.hadders-algra@med.umcg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / administration & dosage Brain / growth & development* Diet* Dietary Fats, Unsaturated / administration & dosage* Dietary Supplements Docosahexaenoic Acids / administration & dosage Fatty Acids, Unsaturated / administration & dosage* Female Humans Pregnancy Prenatal Nutritional Physiological Phenomena* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
| Comments/Corrections | |
Comment In:
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J Perinat Med. 2008;36(3):265-7; author reply 268-9
[PMID:
18576939
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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