| Prenatal ischemia and white matter damage in rats. | |
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MedLine Citation:
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PMID: 16254494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ischemia/reperfusion injury to the developing brain is a major cause of neurologic abnormalities in preterm infants. To investigate the underlying mechanisms, we modified a previously described rat model of unilateral uterine-artery ligation on the 17th embryonic day (E17). Growth retardation was taken as an index of in utero ischemia, and pups born with a birth weight more than 2 standard deviations below that of controls were compared with the same-litter, normal-growth control pups born from the nonligated horn. Prenatal ischemia probably associated with hypoxia and followed by reperfusion at birth induced white matter damage at a developmental stage corresponding to extreme prematurity in humans. On P0 (day of birth), growth-retarded pups exhibited lesions in the cingular white matter and internal capsule with increased counts of activated microglial cells for 2 weeks compared with controls. Astrogliosis was detected in the injured white matter. On P3, increased apoptotic cell death was seen in O4-positive preoligodendrocytes, which were abnormally scarce on P7. Defective myelination, as assessed by myelin-binding-protein labeling, was detected until adulthood. The diffuse white matter damage in growth-retarded rats replicated the main features of white matter damage in human preterm infants. |
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Authors:
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Paul Olivier; Olivier Baud; Philippe Evrard; Pierre Gressens; Catherine Verney |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuropathology and experimental neurology Volume: 64 ISSN: 0022-3069 ISO Abbreviation: J. Neuropathol. Exp. Neurol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-28 Completed Date: 2005-12-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985192R Medline TA: J Neuropathol Exp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 998-1006 Citation Subset: IM |
Affiliation:
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INSERM U676-Université Paris7, Robert Debré Pediatric Hospital, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Antigens, CD11b / metabolism Brain Diseases / metabolism, pathology* Caspase 3 Caspases / metabolism Cell Count / methods Cell Death Disease Models, Animal Embryo, Mammalian Female Gene Expression Regulation, Developmental / physiology Glial Fibrillary Acidic Protein / metabolism Glucose Transporter Type 2 / metabolism Hypoxia-Ischemia, Brain / metabolism, pathology* Immunohistochemistry / methods In Situ Nick-End Labeling / methods Male Myelin Basic Proteins / metabolism Neovascularization, Pathologic / metabolism, pathology O Antigens / metabolism Plant Lectins / metabolism Pregnancy Rats Rats, Sprague-Dawley Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD11b; 0/Glial Fibrillary Acidic Protein; 0/Glucose Transporter Type 2; 0/Myelin Basic Proteins; 0/O Antigens; 0/Plant Lectins; 0/tomato lectin; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Casp3 protein, rat; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases |
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