Document Detail

Prenatal and intrapartum events and sudden infant death syndrome.
MedLine Citation:
PMID:  11856458     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate specific pregnancy and labour and delivery events that may increase the risk of sudden infant death syndrome (SIDS). A matched case-control study was conducted in five counties in southern California, using California death certificate records. The sample consisted of 239 Caucasian, African-American, Hispanic and Asian mothers of SIDS infants and 239 mothers of control infants matched on sex, race, birth hospital and date of birth. Mothers participated in a detailed telephone interview and provided access to obstetric and paediatric records. More case than control mothers reported a family history of anaemia (OR=2.12, P < 0.001). Placental abruptions were strongly associated with SIDS (unadjusted OR=7.94, [95% CI 1.34,47.12]). There was an increased risk of SIDS death associated with maternal anaemia during pregnancy (OR=2.51, [95% CI 1.25,5.03]), while simultaneously adjusting for maternal smoking during pregnancy, maternal years of education and age, parity, infant birthweight, gestational age, medical conditions at birth, infant sleep position and post-natal smoking. Interactions of anaemia and prenatal smoking as well as anaemia and post-natal smoking were not statistically significant. There were no other statistically significant differences between case and control mothers for pregnancy conditions, labour and delivery events (e.g. caesarean sections, anaesthesia, forceps) or newborn complications (e.g. nuchal cord, meconium aspiration). Anaemia and placental abruptions were significantly associated with an increased risk of SIDS; both are circumstances in which a fetus may become hypoxic, thereby compromising the subsequent growth, development and ultimate survival of the infant.
Hillary S Klonoff-Cohen; Indu P Srinivasan; Sharon L Edelstein
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  16     ISSN:  0269-5022     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-21     Completed Date:  2002-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  82-9     Citation Subset:  IM    
Department of Family and Preventive Medicine, Division of Epidemiology, University of California San Diego, La Jolla, CA 92093-0607, USA.
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MeSH Terms
Abruptio Placentae / complications,  epidemiology
Anemia / complications,  epidemiology
California / epidemiology
Case-Control Studies
Death Certificates
Delivery, Obstetric
Labor, Obstetric
Pregnancy Complications / epidemiology*
Pregnancy Complications, Hematologic / epidemiology
Pregnancy Trimesters
Risk Factors
Sudden Infant Death / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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