Document Detail

Prenatal increased asymmetric dimethylarginine is associated with placental heat-shock protein 70 and lectin-like oxidized low-density lipoprotein receptor-1 expression.
MedLine Citation:
PMID:  17923264     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction by reversibly blocking NO production from L-arginine. To elucidate the association of prenatal status of ADMA with placental heat-shock protein 70 (HSP70) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in normal full-term pregnancies, we evaluated the expression of placental HSP70 and LOX-1. METHODS: Tissue samples of placentas obtained from 60 normal-term pregnancies were categorized into 30 cases with a lower level of prenatal ADMA (0.28 +/- 0.07 microM) and 30 cases with a higher level of prenatal ADMA (1.31 +/- 0.44 microM). We evaluated the placental expression of HSP70 and LOX-1 with Western blot analysis and immunohistochemistry and determined the correlation between HSP70 and LOX-1. RESULTS: We found that prenatal increased ADMA is associated with increased placental HSP70 and LOX-1 expression. CONCLUSIONS: We postulate that higher ADMA levels are associated with excessive levels of oxidative damage and stress markers (HSP, LOX-1) in placental tissues.
Young Ju Kim; Yeo Jin Jeon; Young Mo Ahn; Hwa Young Lee; So Yeon Woo; Hye Sook Park; Eun Hee Ha; Myung Geol Pang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-20
Journal Detail:
Title:  Archives of medical research     Volume:  38     ISSN:  0188-4409     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-09     Completed Date:  2007-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  839-45     Citation Subset:  IM    
Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Korea.
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MeSH Terms
Arginine / analogs & derivatives*,  blood,  metabolism
Blotting, Western
HSP70 Heat-Shock Proteins / metabolism*
Nitric Oxide / antagonists & inhibitors
Placenta / metabolism*
Scavenger Receptors, Class E / metabolism*
Term Birth / blood,  metabolism
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; 0/Scavenger Receptors, Class E; 10102-43-9/Nitric Oxide; 30344-00-4/N,N'-dimethylarginine; 74-79-3/Arginine

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