| Prenatal increased asymmetric dimethylarginine is associated with placental heat-shock protein 70 and lectin-like oxidized low-density lipoprotein receptor-1 expression. | |
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MedLine Citation:
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PMID: 17923264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction by reversibly blocking NO production from L-arginine. To elucidate the association of prenatal status of ADMA with placental heat-shock protein 70 (HSP70) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in normal full-term pregnancies, we evaluated the expression of placental HSP70 and LOX-1. METHODS: Tissue samples of placentas obtained from 60 normal-term pregnancies were categorized into 30 cases with a lower level of prenatal ADMA (0.28 +/- 0.07 microM) and 30 cases with a higher level of prenatal ADMA (1.31 +/- 0.44 microM). We evaluated the placental expression of HSP70 and LOX-1 with Western blot analysis and immunohistochemistry and determined the correlation between HSP70 and LOX-1. RESULTS: We found that prenatal increased ADMA is associated with increased placental HSP70 and LOX-1 expression. CONCLUSIONS: We postulate that higher ADMA levels are associated with excessive levels of oxidative damage and stress markers (HSP, LOX-1) in placental tissues. |
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Authors:
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Young Ju Kim; Yeo Jin Jeon; Young Mo Ahn; Hwa Young Lee; So Yeon Woo; Hye Sook Park; Eun Hee Ha; Myung Geol Pang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-20 |
Journal Detail:
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Title: Archives of medical research Volume: 38 ISSN: 0188-4409 ISO Abbreviation: Arch. Med. Res. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-09 Completed Date: 2007-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 839-45 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Korea. kkyj@ewha.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arginine
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analogs & derivatives*,
blood,
metabolism Blotting, Western Female HSP70 Heat-Shock Proteins / metabolism* Humans Immunohistochemistry Nitric Oxide / antagonists & inhibitors Placenta / metabolism* Pregnancy Scavenger Receptors, Class E / metabolism* Term Birth / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; 0/Scavenger Receptors, Class E; 10102-43-9/Nitric Oxide; 30344-00-4/N,N'-dimethylarginine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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