| Prenatal imprinting of postnatal specific appetites and feeding behavior. | |
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MedLine Citation:
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PMID: 18803961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epigenetic influences on the fetus's genotype have been shown to occur during intrauterine life. Experimentally imposed extracellular dehydration in pregnant rats (a model for human hyponatremia caused by gravidic vomiting) brings about a dramatic enhancement of salt appetite not only in the dam, but also in offspring when they reach adulthood. This phenomenon has been verified in human newborn infants and adults whose mothers experienced nausea and/or vomiting during pregnancy. Alcohol consumption during pregnancy enhances its palatability for the offspring. Ingestion of olfactory test substances like anise or carrot by the mother during pregnancy gives rise to a preference for the same testants in the offspring. Under- or overnutrition in the pregnant mother appears to play a role in reprogramming the postnatal regulation of both feeding and fat reserves in offspring. Both maternal under- and overnutrition during pregnancy predispose the offspring to later development of obesity and type 2 diabetes mellitus. A careful examination of the systems concerned with the regulation of food intake, and the neurosubstances involved in such regulation, reveals some of the mechanisms by which maternal nutritional status can affect the offspring and their food-related behaviors. |
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Authors:
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Stylianos Nicolaïdis |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 57 Suppl 2 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2008-10-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: S22-6 Citation Subset: IM |
Affiliation:
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snicolaidis@laposte.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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pathology Animals Appetite / genetics*, physiology Drinking / physiology Embryonic Development / genetics* Feeding Behavior / physiology* Female Food Preferences / physiology Genomic Imprinting / physiology* Humans Olfactory Pathways / drug effects, embryology Pregnancy Pregnancy Complications / pathology Prenatal Nutritional Physiological Phenomena / drug effects, genetics Sodium Chloride, Dietary / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Sodium Chloride, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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