Document Detail

Prenatal high-salt diet in the Sprague-Dawley rat programs blood pressure and heart rate hyperresponsiveness to stress in adult female offspring.
MedLine Citation:
PMID:  17491116     Owner:  NLM     Status:  MEDLINE    
Several animal models have been developed to study fetal programming of hypertension. One model involves feeding high-salt (HS) diet to rats before and during pregnancy, during lactation, and after weaning for 10 days. In the present investigation, we limited HS diet to the prenatal period in an attempt to find a narrower critical window for fetal programming. The HS diet did not result in low-birth weight offspring. In the adult offspring, radiotelemetry was used to assess blood pressure and heart rate in the conscious unstressed state. As adults, the HS offspring were not hypertensive compared with normal-salt (NS) control animals. However, the pressor and tachycardic responses to 1-h of restraint were significantly enhanced in HS female offspring, and recovery after restraint was delayed. This was accompanied by an increase in relative expression of corticotropin-releasing hormone (CRH) mRNA in the paraventricular nucleus of the hypothalamus during basal and stressed conditions. There was no augmented stress response or relative increase in CRH mRNA in adult HS male offspring. When challenged with 1 wk of 8% NaCl diet as adults, neither HS male nor female offspring exhibited salt sensitivity compared with NS groups. These data show that a high-salt diet limited to the prenatal period is not sufficient to program hypertension in adult offspring. However, this narrower critical period is sufficient to imprint a lasting hyperresponsiveness to stress, at least in adult female offspring. These data indicate that excessive maternal salt intake during pregnancy can adversely affect the cardiovascular health of adult offspring.
James P Porter; Summer H King; April D Honeycutt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-09
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  293     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R334-42     Citation Subset:  IM    
Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.
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MeSH Terms
Birth Weight / physiology
Blood Pressure / physiology*
Corticosterone / blood
Corticotropin-Releasing Hormone / biosynthesis
Data Interpretation, Statistical
Drinking / physiology
Eating / physiology
Heart Rate / physiology*
In Situ Hybridization
Litter Size
Paraventricular Hypothalamic Nucleus / physiology
Prenatal Exposure Delayed Effects / physiopathology*
RNA, Messenger / biosynthesis,  genetics
Rats, Sprague-Dawley
Sex Ratio
Sodium, Dietary / pharmacology*
Stress, Psychological / physiopathology*
Reg. No./Substance:
0/RNA, Messenger; 0/Sodium, Dietary; 50-22-6/Corticosterone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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