Document Detail


Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons.
MedLine Citation:
PMID:  16406151     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal treatment with synthetic glucocorticoids is commonly used as a treatment for women at risk of preterm delivery. However, little is known about the life-long consequences of these treatments on the fetus. In the present study, we evaluated cognitive function as well as susceptibility of cholinergic neurons to (192)IgG-saporin immunolesion in adult rats after prenatal glucocorticoid treatment. Morris water maze results revealed a significant difference in learning and memory function in adult rats that were prenatally exposed to dexamethasone, and further cognitive deficits after (192)IgG-saporin exposure. Choline acetyl transferase activity was decreased in the cortex of dexamethasone-treated rats compared with controls. In addition, rats prenatally exposed to either dexa, or betamethasone revealed a dramatic decrease in choline acetyl transferase activity compared to control rats after (192)IgG-saporin lesion. We report behavioral and biochemical evidence for altered cognitive function and increased susceptibility of cholinergic neurons to (192)IgG-saporin in adult rats after prenatal glucocorticoid treatment. Taken together, these results suggest that prenatal treatment with dexamethasone could affect cognitive functions and render cholinergic neurons more vulnerable to challenges later in life.
Authors:
Mia Emgård; Michela Paradisi; Stefania Pirondi; Mercedes Fernandez; Luciana Giardino; Laura Calzà
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-06
Journal Detail:
Title:  Neurobiology of aging     Volume:  28     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2006-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-21     Citation Subset:  IM    
Affiliation:
Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia Bologna, Italy. mia.emgard@neurotec.ki.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / drug effects,  metabolism
Cognition Disorders / chemically induced,  physiopathology
Dexamethasone / adverse effects*
Disease Susceptibility / chemically induced,  physiopathology
Female
Male
Maternal-Fetal Exchange
Maze Learning / drug effects*,  physiology*
Neurons / metabolism*
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced*,  physiopathology*
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic / metabolism*
Chemical
Reg. No./Substance:
0/Receptors, Nicotinic; 50-02-2/Dexamethasone

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