Document Detail

Prenatal genetic testing by amniocentesis appears to result in a lower risk of fetal loss than chorionic villus sampling in singleton pregnancies achieved by intracytoplasmic sperm injection.
MedLine Citation:
PMID:  12568848     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare pregnancy outcome after prenatal genetic testing by chorionic villus sampling (CVS) or amniocentesis in singleton pregnancies achieved by intracytoplasmic sperm injection (ICSI). DESIGN: Retrospective analysis. SETTING: Tertiary referral center. PATIENT(S): Eight hundred twenty-eight patients with singleton gestations achieved by ICSI. INTERVENTION(S): Midtrimester amniocentesis (685 patients) and first-trimester CVS (143 patients). MAIN OUTCOME MEASURE(S): Fetal loss rate, preterm delivery rate, and proportion of babies born with low or very low birth weight. RESULT(S): A significant difference was observed in fetal loss rate between CVS and amniocentesis (3.7% vs. 0.9%, respectively). On the other hand, a similar preterm delivery rate was present between the two methods (11.2% vs. 12.4%, respectively). No significant difference was observed between amniocentesis and CVS in the proportion of babies with birth weight of either <1,500 g (1.8% vs. 3.8%, respectively) or between 1,500 and 2,500 g (8.2% vs. 4.6%, respectively). CONCLUSION(S): Amniocentesis appears to result in a lower risk of fetal loss as compared with CVS in patients with a singleton pregnancy achieved by ICSI.
Efstratios Kolibianakis; Kaan Osmanagaoglu; Luc De Catte; Michel Camus; Maryse Bonduelle; Inge Liebaers; Andre Van Steirteghem; Paul Devroey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  79     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-05     Completed Date:  2003-04-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-8     Citation Subset:  IM    
Centre for Reproductive Medicine, University Hospital and Medical School, Dutch-Speaking Brussels Free University, Brussels, Belgium.
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MeSH Terms
Abortion, Spontaneous / prevention & control*
Amniocentesis / standards*
Chorionic Villi Sampling / standards*
Congenital Abnormalities / epidemiology,  genetics
Genetic Testing / methods*
Gestational Age
Maternal Age
Middle Aged
Retrospective Studies
Risk Factors
Sperm Injections, Intracytoplasmic*
Treatment Failure

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