Document Detail


Prenatal exposure to traffic-related air pollution and fetal growth in a cohort of pregnant women.
MedLine Citation:
PMID:  22843441     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ObjectivesScant evidence is available on effects of air pollution on longitudinally measured fetal biometry, and thus it remains unclear as to whether there are critical windows of exposure or specificity of effects. Our objective was to examine the association between exposure to nitrogen dioxide (NO(2)) during pregnancy and fetal and neonatal anthropometry in a cohort of Spanish women.MethodsTemporally adjusted land-use regression was used to estimate exposure to NO(2) at home addresses. Biparietal diameter (BPD), abdominal circumference (AC), femur length (FL) and estimated fetal weight (EFW) were evaluated in each trimester by ultrasound. As neonatal outcomes, weight, length and head circumference were analysed. SD scores adjusted by gestational age, mother characteristics and fetus sex were calculated at 12, 20 and 32 weeks of gestation as well as at birth. The association between fetal growth and average exposure to NO(2) in the relevant windows was investigated using regression models, adjusted for socio-demographic and lifestyle-related variables.ResultsExposure to NO(2) was inversely associated with BPD, AC and EFW at week 32 and with growth in these parameters in weeks 20-32. BPD and FL were also affected earlier, at week 20. NO(2) levels above the median (38 μg/m(3)) reduced size at week 32 by around 9% in all parameters except for FL (6%). The critical windows of exposure were in early pregnancy, before 20 weeks. Exposure in this period was also inversely associated with neonatal length and head circumference.ConclusionsMaternal exposure to NO(2) is associated with impaired fetal growth from mid-gestation onwards.
Authors:
Carmen Iñiguez; Ferran Ballester; Marisa Estarlich; Ana Esplugues; Mario Murcia; Sabrina Llop; Alfredo Plana; Rubén Amorós; Marisa Rebagliato
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-27
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  -     ISSN:  1470-7926     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Center for Public Health Research-CSISP, Conselleria de Sanitat, Valencia, Spain.
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