| Prenatal exposure to nicotine with associated in utero hypoxia decreased fetal brain muscarinic mRNA in the rat. | |
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MedLine Citation:
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PMID: 18053972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prenatal exposure to nicotine can be associated with fetal abnormal development and brain damage. This study determined the effect of administration of nicotine with associated in utero hypoxia in maternal rats from early, middle, and late gestation on fetal blood hemoglobin, and expression of cholinergic receptor subtypes in the fetal brain. Our results demonstrated that maternal subcutaneous nicotine from the early gestation increased fetal hemoglobin and hematocrit, associated with reduction of PO(2). Although exposure to nicotine during late gestation had no effects on fetal brain weight, nicotine administration from the early gestation significantly decreased fetal brain muscarinic receptor (M1, M2, M3, and M4) mRNA expression, associated with restricted brain growth. Nicotine-altered muscarinic receptor subtype expression in the fetal forebrain and hindbrain showed regional differences. In addition, there were gestational differences for fetal brain muscarinic suppression by prenatal nicotine. Together, the results demonstrate that nicotine-induced in utero hypoxia is associated with poor development of muscarinic receptors in the fetal brain and restricted brain growth, and that either prolonged prenatal exposure to nicotine or critical "window" period for the brain development during pregnancy may play a role in prenatal nicotine-induced fetal muscarinic-receptor deficiency in the fetal brain. |
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Authors:
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Caiping Mao; Xin Yuan; Yugui Cui; Hong Li; Juanxiu Lv; Xing Feng; Yujuan Liu; Linqi Chen; Zhice Xu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-09 |
Journal Detail:
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Title: Brain research Volume: 1189 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 43-50 Citation Subset: IM |
Affiliation:
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Perinatal Biology Center, Soochow University School of Medicine and Affiliated Children's Hospital, Suzhou, 215007, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, embryology, physiopathology Down-Regulation / drug effects, genetics Female Fetal Hypoxia / chemically induced, genetics*, metabolism Gene Expression Regulation, Developmental / drug effects, genetics Hematocrit Hypoxia, Brain / chemically induced, genetics*, metabolism Nicotine / adverse effects* Nicotinic Agonists / adverse effects Oxygen / blood Pregnancy Prenatal Exposure Delayed Effects / genetics*, metabolism, physiopathology RNA, Messenger / drug effects, metabolism* Rats Rats, Sprague-Dawley Receptors, Muscarinic / deficiency, genetics* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Nicotinic Agonists; 0/RNA, Messenger; 0/Receptors, Muscarinic; 54-11-5/Nicotine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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