Document Detail


Prenatal exposure to nicotine with associated in utero hypoxia decreased fetal brain muscarinic mRNA in the rat.
MedLine Citation:
PMID:  18053972     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal exposure to nicotine can be associated with fetal abnormal development and brain damage. This study determined the effect of administration of nicotine with associated in utero hypoxia in maternal rats from early, middle, and late gestation on fetal blood hemoglobin, and expression of cholinergic receptor subtypes in the fetal brain. Our results demonstrated that maternal subcutaneous nicotine from the early gestation increased fetal hemoglobin and hematocrit, associated with reduction of PO(2). Although exposure to nicotine during late gestation had no effects on fetal brain weight, nicotine administration from the early gestation significantly decreased fetal brain muscarinic receptor (M1, M2, M3, and M4) mRNA expression, associated with restricted brain growth. Nicotine-altered muscarinic receptor subtype expression in the fetal forebrain and hindbrain showed regional differences. In addition, there were gestational differences for fetal brain muscarinic suppression by prenatal nicotine. Together, the results demonstrate that nicotine-induced in utero hypoxia is associated with poor development of muscarinic receptors in the fetal brain and restricted brain growth, and that either prolonged prenatal exposure to nicotine or critical "window" period for the brain development during pregnancy may play a role in prenatal nicotine-induced fetal muscarinic-receptor deficiency in the fetal brain.
Authors:
Caiping Mao; Xin Yuan; Yugui Cui; Hong Li; Juanxiu Lv; Xing Feng; Yujuan Liu; Linqi Chen; Zhice Xu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-09
Journal Detail:
Title:  Brain research     Volume:  1189     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Affiliation:
Perinatal Biology Center, Soochow University School of Medicine and Affiliated Children's Hospital, Suzhou, 215007, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects,  embryology,  physiopathology
Down-Regulation / drug effects,  genetics
Female
Fetal Hypoxia / chemically induced,  genetics*,  metabolism
Gene Expression Regulation, Developmental / drug effects,  genetics
Hematocrit
Hypoxia, Brain / chemically induced,  genetics*,  metabolism
Nicotine / adverse effects*
Nicotinic Agonists / adverse effects
Oxygen / blood
Pregnancy
Prenatal Exposure Delayed Effects / genetics*,  metabolism,  physiopathology
RNA, Messenger / drug effects,  metabolism*
Rats
Rats, Sprague-Dawley
Receptors, Muscarinic / deficiency,  genetics*
Time Factors
Chemical
Reg. No./Substance:
0/Nicotinic Agonists; 0/RNA, Messenger; 0/Receptors, Muscarinic; 54-11-5/Nicotine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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