Document Detail


Prenatal exposure to maternal depression and cortisol influences infant temperament.
MedLine Citation:
PMID:  17513986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Accumulating evidence indicates that prenatal maternal and fetal processes can have a lasting influence on infant and child development. Results from animal models indicate that prenatal exposure to maternal stress and stress hormones has lasting consequences for development of the offspring. Few prospective studies of human pregnancy have examined the consequences of prenatal exposure to stress and stress hormones. METHOD: In this study the effects of prenatal maternal psychosocial (anxiety, depression, and perceived stress) and endocrine (cortisol) indicators of stress on infant temperament were examined in a sample of 247 full-term infants. Maternal salivary cortisol and psychological state were evaluated at 18-20, 24-26, and 30-32 weeks of gestation and at 2 months postpartum. Infant temperament was assessed with a measure of negative reactivity (the fear subscale of the Infant Temperament Questionnaire) at 2 months of age. RESULTS: Elevated maternal cortisol at 30-32 weeks of gestation, but not earlier in pregnancy, was significantly associated with greater maternal report of infant negative reactivity. Prenatal maternal anxiety and depression additionally predicted infant temperament. The associations between maternal cortisol and maternal depression remained after controlling for postnatal maternal psychological state. CONCLUSIONS: These data suggest that prenatal exposure to maternal stress has consequences for the development of infant temperament.
Authors:
Elysia Poggi Davis; Laura M Glynn; Christine Dunkel Schetter; Calvin Hobel; Aleksandra Chicz-Demet; Curt A Sandman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  46     ISSN:  0890-8567     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-07-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-46     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Human Behavior, University of California, Irvine, USA. edavis@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Depressive Disorder / metabolism*,  psychology
Female
Fetal Development
Humans
Hydrocortisone / metabolism*
Infant
Infant Behavior / physiology*
Pregnancy
Pregnancy Complications / metabolism*,  psychology
Prenatal Exposure Delayed Effects / psychology*
Prospective Studies
Stress, Psychological / metabolism*,  psychology
Temperament / physiology*
Grant Support
ID/Acronym/Agency:
HD28413/HD/NICHD NIH HHS; NS-41298/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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