| Prenatal exposure to a farm environment modifies atopic sensitization at birth. | |
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MedLine Citation:
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PMID: 18678343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age. OBJECTIVE: We sought to evaluate the effects of maternal exposure to animal sheds and other farm-related exposures during pregnancy on cord blood IgE levels in a prospective birth cohort. METHODS: Pregnant women living in rural areas in Austria, Finland, France, Germany, and Switzerland were recruited in the third trimester of pregnancy. Information on maternal farm-related exposures, nutrition, and health during pregnancy was obtained by means of interviews. Specific IgE levels for food and common inhalant allergens were assessed in cord blood of 922 children and peripheral blood samples of their mothers. RESULTS: Different sensitization patterns in cord blood of farm and nonfarm children were observed. In multivariable analysis consumption of boiled, but not unboiled, farm milk during pregnancy was positively associated with specific IgE to cow's milk independently from maternal IgE. In contrast, there was an inverse relationship between maternal exposure to animal sheds and cord blood IgE levels against seasonal allergens (adjusted odds ratio, 0.38; 95% CI, 0.21-0.70). This association was not confounded by maternal IgE levels. Maternal contact with hay enhanced the protective effect of exposure to animal sheds on IgE levels to grass pollen in cord blood. CONCLUSIONS: Maternal exposure during pregnancy influences atopic sensitization patterns in cord blood. The (microbial) context of allergen contact possibly modifies the risk of atopic sensitization. |
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Authors:
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Markus Johannes Ege; Ileana Herzum; Gisela Büchele; Susanne Krauss-Etschmann; Roger P Lauener; Marjut Roponen; Anne Hyvärinen; Dominique A Vuitton; Josef Riedler; Bert Brunekreef; Jean-Charles Dalphin; Charlotte Braun-Fahrländer; Juha Pekkanen; Harald Renz; Erika von Mutius; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 122 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-05 Completed Date: 2008-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 407-12, 412.e1-4 Citation Subset: AIM; IM |
Affiliation:
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University Children's Hospital, Munich, Germany. markus.ege@med.uni-muenchen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agriculture* Allergens / immunology* Animals Animals, Domestic Cohort Studies Environmental Exposure* Europe / epidemiology Female Fetal Blood / immunology* Humans Hypersensitivity, Immediate / epidemiology*, immunology* Immunoglobulin E / blood* Infant, Newborn Logistic Models Male Maternal Exposure / adverse effects* Pregnancy Prospective Studies Questionnaires |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 37341-29-0/Immunoglobulin E |
| Investigator | |
Investigator/Affiliation:
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Gertraud Weiss / ; Ellen Ublagger / ; Claudia Humer / ; Manuela Russegger / ; Raija Juntunen / ; Reetta Tiihonen / ; Pekka Tiittanen / ; Maija-Riitta Hirvonen / ; Kati Huttunen / ; Suvi Virtanen / ; Timo Kauppila / ; Aino Nevalainen / ; Sami Remes / ; Tomi-Pekka Tuomainen / ; Anne Karvonen / ; Marie-Laure Dalphin / ; Renaud Piarroux / ; Gabriel Reboux / ; Sandrine Roussel / ; Bertrand Sudre / ; Susanne Schmid / ; Sabina Illi / ; Nicola Korherr / ; Jon Genuneit / ; Richard Peter / ; Serdar Sel / ; Nicole Blümer / ; Petra Pfefferle / ; Ulrike Gehring / ; Sondhja Bitter / ; Felix H Sennhauser / ; Susanne Loeliger / ; Johanna Steinle / ; Remo Frei / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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