Document Detail

Prenatal exposure to ethanol induces changes in the nerve growth factor and its receptor in proliferating astrocytes in primary culture.
MedLine Citation:
PMID:  7820588     Owner:  NLM     Status:  MEDLINE    
We have analyzed the effect of prenatal exposure to alcohol on the binding, internalization and secretion of NGF as well as on the content of the NGF receptor (NGFr) in cortical rat astrocytes in primary culture. Secretion of NGF was approximately 1.8-fold greater in 6-day control astrocytes than in 13-day cells. Intracellular content of NGF was very low. Astrocytes in 6-day cultures from control fetuses expressed a relatively large number of NGFr on the cell surface with a steady-state constant in the low nanomolar range. NGF was internalized by astrocytes at a slow rate. Prenatal exposure to ethanol induces a moderate increase in the number of NGFr on the cell surface as well as an increase in the intracellular pool of both NGF and NGFr which is accompanied by an important reduction in the secretion of this factor. We speculate that this decrease in NGF secretion could alter the neuronal migration pattern during development, resulting in the presence of ectopic neurons in the cortex.
S Vallés; L Lindo; C Montoliu; J Renau-Piqueras; C Guerri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  656     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-14     Completed Date:  1995-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Instituto Investigaciones Citológicas, Valencia, Spain.
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MeSH Terms
Astrocytes / drug effects,  metabolism*
Cell Division / drug effects
Cells, Cultured
Cerebral Cortex / cytology,  drug effects
Ethanol / toxicity*
Glial Fibrillary Acidic Protein / metabolism
Nerve Growth Factors / metabolism*
Prenatal Exposure Delayed Effects*
Rats, Wistar
Receptors, Nerve Growth Factor / metabolism*
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 0/Nerve Growth Factors; 0/Receptors, Nerve Growth Factor; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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